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TWO SIGMA INVESTMENTS, LP
> SPRO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Spero Therapeutics, Inc. | SPRO | 84,535 | 52,435 | 122,576,000 | 76,031,000 | $1,450.00 |
| 03/31/2023 | Spero Therapeutics, Inc. | SPRO | 32,100 | -7,695 | 46,545,000 | -22,300,000 | $1,450.00 |
| 12/31/2022 | Spero Therapeutics, Inc. | SPRO | 39,795 | -397,485 | 68,845,000 | 68,521,000 | $1,729.99 |
| 06/30/2022 | Spero Therapeutics, Inc. | SPRO | 437,280 | 358,372 | 324,000 | -362,000 | $0.74 |
| 03/31/2022 | Spero Therapeutics, Inc. | SPRO | 78,908 | 78,908 | 686,000 | 686,000 | $8.69 |
| 03/31/2021 | Spero Therapeutics, Inc. | SPRO | 0 | -43,373 | 0 | -841,000 | |
| 12/31/2020 | Spero Therapeutics, Inc. | SPRO | 43,373 | 43,373 | 841,000 | 841,000 | $19.39 |
| 09/30/2020 | Spero Therapeutics, Inc. | SPRO | 0 | -28,150 | 0 | -381,000 | |
| 06/30/2020 | Spero Therapeutics, Inc. | SPRO | 28,150 | 28,150 | 381,000 | 381,000 | $13.53 |
| 03/31/2020 | Spero Therapeutics, Inc. | SPRO | 0 | -18,828 | 0 | -181,000 | |
| 12/31/2019 | Spero Therapeutics, Inc. | SPRO | 18,828 | 18,828 | 181,000 | 181,000 | $9.61 |
| 03/31/2019 | Spero Therapeutics, Inc. | SPRO | 0 | -27,454 | 0 | -169,000 | |
| 12/31/2018 | Spero Therapeutics, Inc. | SPRO | 27,454 | 27,454 | 169,000 | 169,000 | $6.16 |
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