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TWO SIGMA INVESTMENTS, LP
> VNDA
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Vanda Pharmaceuticals Inc. | VNDA | 669,084 | 160,828 | 4,409,264,000 | 958,206,000 | $6,590.00 |
| 03/31/2023 | Vanda Pharmaceuticals Inc. | VNDA | 508,256 | 61,885 | 3,451,058,000 | 152,376,000 | $6,790.00 |
| 12/31/2022 | Vanda Pharmaceuticals Inc. | VNDA | 446,371 | 37,003 | 3,298,682,000 | 3,294,220,000 | $7,390.00 |
| 06/30/2022 | Vanda Pharmaceuticals Inc. | VNDA | 409,368 | 106,235 | 4,462,000 | 1,034,000 | $10.90 |
| 03/31/2022 | Vanda Pharmaceuticals Inc. | VNDA | 303,133 | -28,126 | 3,428,000 | -1,769,000 | $11.31 |
| 12/31/2021 | Vanda Pharmaceuticals Inc. | VNDA | 331,259 | 209,014 | 5,197,000 | 3,102,000 | $15.69 |
| 09/30/2021 | Vanda Pharmaceuticals Inc. | VNDA | 122,245 | -121,596 | 2,095,000 | -3,150,000 | $17.14 |
| 06/30/2021 | Vanda Pharmaceuticals Inc. | VNDA | 243,841 | 63,254 | 5,245,000 | 2,533,000 | $21.51 |
| 03/31/2021 | Vanda Pharmaceuticals Inc. | VNDA | 180,587 | 132,330 | 2,712,000 | 2,078,000 | $15.02 |
| 12/31/2020 | Vanda Pharmaceuticals Inc. | VNDA | 48,257 | 48,257 | 634,000 | 634,000 | $13.14 |
| 09/30/2020 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -105,003 | 0 | -1,201,000 | |
| 06/30/2020 | Vanda Pharmaceuticals Inc. | VNDA | 105,003 | -62,408 | 1,201,000 | -533,000 | $11.44 |
| 03/31/2020 | Vanda Pharmaceuticals Inc. | VNDA | 167,411 | -225,307 | 1,734,000 | -4,711,000 | $10.36 |
| 12/31/2019 | Vanda Pharmaceuticals Inc. | VNDA | 392,718 | 162,179 | 6,445,000 | 3,383,000 | $16.41 |
| 09/30/2019 | Vanda Pharmaceuticals Inc. | VNDA | 230,539 | -211,463 | 3,062,000 | -3,166,000 | $13.28 |
| 06/30/2019 | Vanda Pharmaceuticals Inc. | VNDA | 442,002 | 39,038 | 6,228,000 | -1,187,000 | $14.09 |
| 03/31/2019 | Vanda Pharmaceuticals Inc. | VNDA | 402,964 | 78,655 | 7,415,000 | -1,059,000 | $18.40 |
| 12/31/2018 | Vanda Pharmaceuticals Inc. | VNDA | 324,309 | -36,050 | 8,474,000 | 204,000 | $26.13 |
| 09/30/2018 | Vanda Pharmaceuticals Inc. | VNDA | 360,359 | 5,608 | 8,270,000 | 1,512,000 | $22.95 |
| 06/30/2018 | Vanda Pharmaceuticals Inc. | VNDA | 354,751 | 180,314 | 6,758,000 | 3,819,000 | $19.05 |
| 03/31/2018 | Vanda Pharmaceuticals Inc. | VNDA | 174,437 | 156,037 | 2,939,000 | 2,659,000 | $16.85 |
| 12/31/2017 | Vanda Pharmaceuticals Inc. | VNDA | 18,400 | -185,558 | 280,000 | -3,371,000 | $15.22 |
| 09/30/2017 | Vanda Pharmaceuticals Inc. | VNDA | 203,958 | 13,376 | 3,651,000 | 545,000 | $17.90 |
| 06/30/2017 | Vanda Pharmaceuticals Inc. | VNDA | 190,582 | 156,847 | 3,106,000 | 2,634,000 | $16.30 |
| 03/31/2017 | Vanda Pharmaceuticals Inc. | VNDA | 33,735 | -162,331 | 472,000 | -2,655,000 | $13.99 |
| 12/31/2016 | Vanda Pharmaceuticals Inc. | VNDA | 196,066 | 20,287 | 3,127,000 | 202,000 | $15.95 |
| 09/30/2016 | Vanda Pharmaceuticals Inc. | VNDA | 175,779 | 77,164 | 2,925,000 | 1,821,000 | $16.64 |
| 06/30/2016 | Vanda Pharmaceuticals Inc. | VNDA | 98,615 | 98,615 | 1,104,000 | 1,104,000 | $11.20 |
| 03/31/2016 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -184,290 | 0 | -1,489,000 | |
| 06/30/2015 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -184,290 | 0 | -1,489,000 | |
| 03/31/2015 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -184,290 | 0 | -1,489,000 | |
| 12/31/2014 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -184,290 | 0 | -1,489,000 | |
| 09/30/2014 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -184,290 | 0 | -1,489,000 | |
| 06/30/2014 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -184,290 | 0 | -1,489,000 | |
| 03/31/2014 | Vanda Pharmaceuticals Inc. | VNDA | 0 | -184,290 | 0 | -1,489,000 | |
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