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CAPITAL GUARDIAN TRUST CO
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 484,759 | -162,601 | 24,180,000 | -19,945,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 647,360 | 16,981 | 44,125,000 | 15,058,000 | $68.16 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 630,379 | -15,533 | 29,067,000 | -20,746,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 645,912 | -97 | 49,813,000 | -4,600,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 646,009 | -15,253 | 54,413,000 | 335,000 | $84.23 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 661,262 | -1,827 | 54,078,000 | 16,169,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 663,089 | -66,625 | 37,909,000 | -10,799,000 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 729,714 | -51,086 | 48,708,000 | 8,536,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 780,800 | -154,079 | 40,172,000 | -14,425,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 934,879 | 118,679 | 54,597,000 | 20,537,000 | $58.40 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 816,200 | 176,000 | 34,060,000 | 245,000 | $41.73 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 640,200 | -27,900 | 33,815,000 | 5,825,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 668,100 | 253,310 | 27,990,000 | -1,290,000 | $41.89 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 423,922 | 9,132 | 17,211,000 | -12,069,000 | $40.60 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 434,341 | 19,551 | 28,197,000 | -1,083,000 | $64.92 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 414,790 | 414,790 | 29,280,000 | 29,280,000 | $70.59 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 725,780 | 725,780 | 80,663,000 | 80,663,000 | $111.14 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 759,256 | 759,256 | 71,598,000 | 71,598,000 | $94.30 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 674,890 | 674,890 | 75,615,000 | 75,615,000 | $112.04 |
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