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GEODE CAPITAL MANAGEMENT, LLC
> AGLE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Aeglea BioTherapeutics, Inc. | AGLE | 600,455 | 0 | 270,504,000 | 96,373,000 | $450.50 |
| 03/31/2023 | Aeglea BioTherapeutics, Inc. | AGLE | 600,455 | 206,435 | 174,131,000 | 173,924,000 | $290.00 |
| 09/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 394,020 | 0 | 207,000 | 8,000 | $0.53 |
| 06/30/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 394,020 | -298,201 | 199,000 | -1,393,000 | $0.51 |
| 03/31/2022 | Aeglea BioTherapeutics, Inc. | AGLE | 692,221 | 6,476 | 1,592,000 | -1,665,000 | $2.30 |
| 12/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 685,745 | -4,252 | 3,257,000 | -2,228,000 | $4.75 |
| 09/30/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 689,997 | 12,271 | 5,485,000 | 769,000 | $7.95 |
| 06/30/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 677,726 | 19,856 | 4,716,000 | -494,000 | $6.96 |
| 03/31/2021 | Aeglea BioTherapeutics, Inc. | AGLE | 657,870 | 90,857 | 5,210,000 | 748,000 | $7.92 |
| 12/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 567,013 | -1,445 | 4,462,000 | 432,000 | $7.87 |
| 09/30/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 568,458 | -14,186 | 4,030,000 | -1,359,000 | $7.09 |
| 06/30/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 582,644 | 263,564 | 5,389,000 | 3,903,000 | $9.25 |
| 03/31/2020 | Aeglea BioTherapeutics, Inc. | AGLE | 319,080 | 5,909 | 1,486,000 | -906,000 | $4.66 |
| 12/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 313,171 | 14,090 | 2,392,000 | 344,000 | $7.64 |
| 06/30/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 299,081 | 58,345 | 2,048,000 | 111,000 | $6.85 |
| 03/31/2019 | Aeglea BioTherapeutics, Inc. | AGLE | 240,736 | 78,139 | 1,937,000 | 720,000 | $8.05 |
| 12/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 162,597 | 8,310 | 1,217,000 | -259,000 | $7.48 |
| 09/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 154,287 | 6,883 | 1,476,000 | -83,000 | $9.57 |
| 06/30/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 147,404 | 116,755 | 1,559,000 | 1,255,000 | $10.58 |
| 03/31/2018 | Aeglea BioTherapeutics, Inc. | AGLE | 30,649 | 0 | 304,000 | 139,000 | $9.92 |
| 12/31/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 30,649 | 0 | 165,000 | 20,000 | $5.38 |
| 09/30/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 30,649 | 0 | 145,000 | 28,000 | $4.73 |
| 06/30/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 30,649 | -2,493 | 117,000 | 116,754 | $3.82 |
| 03/31/2017 | Aeglea BioTherapeutics, Inc. | AGLE | 33,142 | 33,142 | 246 | 246 | $0.01 |
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