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GEODE CAPITAL MANAGEMENT, LLC
> KPTI
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Karyopharm Therapeutics Inc. | KPTI | 2,137,094 | 365,361 | 3,825,398,000 | -3,066,643,000 | $1,790.00 |
| 03/31/2023 | Karyopharm Therapeutics Inc. | KPTI | 1,771,733 | 441,298 | 6,892,041,000 | 6,884,777,000 | $3,890.00 |
| 09/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 1,330,435 | 4,116 | 7,264,000 | 1,283,000 | $5.46 |
| 06/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 1,326,319 | -11,569 | 5,981,000 | -3,879,000 | $4.51 |
| 03/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 1,337,888 | -104,843 | 9,860,000 | 584,000 | $7.37 |
| 12/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 1,442,731 | 35,574 | 9,276,000 | 1,087,000 | $6.43 |
| 09/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 1,407,157 | 211,879 | 8,189,000 | -4,146,000 | $5.82 |
| 06/30/2021 | Karyopharm Therapeutics Inc. | KPTI | 1,195,278 | 48,563 | 12,335,000 | 272,000 | $10.32 |
| 03/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 1,146,715 | 106,868 | 12,063,000 | -4,033,000 | $10.52 |
| 12/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 1,039,847 | -15,488 | 16,096,000 | 689,000 | $15.48 |
| 09/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 1,055,335 | 22,743 | 15,407,000 | -4,150,000 | $14.60 |
| 06/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 1,032,592 | 99,265 | 19,557,000 | 1,629,000 | $18.94 |
| 03/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 933,327 | 106,355 | 17,928,000 | 2,075,000 | $19.21 |
| 12/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 826,972 | 55,269 | 15,853,000 | 11,231,000 | $19.17 |
| 06/30/2019 | Karyopharm Therapeutics Inc. | KPTI | 771,703 | 185,044 | 4,622,000 | 1,196,000 | $5.99 |
| 03/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 586,659 | 28,732 | 3,426,000 | -1,801,000 | $5.84 |
| 12/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 557,927 | 26,358 | 5,227,000 | -3,825,000 | $9.37 |
| 09/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 531,569 | 15,973 | 9,052,000 | 293,000 | $17.03 |
| 06/30/2018 | Karyopharm Therapeutics Inc. | KPTI | 515,596 | 194,273 | 8,759,000 | 4,447,000 | $16.99 |
| 03/31/2018 | Karyopharm Therapeutics Inc. | KPTI | 321,323 | 40,713 | 4,312,000 | 1,619,000 | $13.42 |
| 12/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 280,610 | 15,489 | 2,693,000 | -218,000 | $9.60 |
| 09/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 265,121 | 4,702 | 2,911,000 | 555,000 | $10.98 |
| 06/30/2017 | Karyopharm Therapeutics Inc. | KPTI | 260,419 | 91,649 | 2,356,000 | 2,353,833 | $9.05 |
| 03/31/2017 | Karyopharm Therapeutics Inc. | KPTI | 168,770 | 168,770 | 2,167 | 2,167 | $0.01 |
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