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FMR LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,628,666 | -1,647,189 | 5,147,973,898,000 | 19,940,173,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,275,855 | -1,090,168 | 5,128,033,725,000 | 5,123,005,566,000 | $315,070.01 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 17,366,023 | 613,012 | 5,028,159,000 | 307,327,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,753,011 | 3,571,298 | 4,720,832,000 | 1,280,801,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,181,713 | 4,087,860 | 3,440,031,000 | 1,443,021,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,093,853 | 4,216,754 | 1,997,010,000 | 1,112,353,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,877,099 | -956,964 | 884,657,000 | -291,665,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,834,063 | -4,337,179 | 1,176,322,000 | -1,009,376,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,171,242 | -2,972,684 | 2,185,698,000 | -920,738,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,143,926 | -6,995,070 | 3,106,436,000 | -2,373,788,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 20,138,996 | 868,479 | 5,480,224,000 | -114,200,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,270,517 | -3,386,072 | 5,594,424,000 | 203,288,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 22,656,589 | -1,204,873 | 5,391,136,000 | 166,669,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 23,861,462 | -870,552 | 5,224,467,000 | 1,034,370,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 24,732,014 | 32,099 | 4,190,097,000 | -339,374,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 24,699,915 | 265,756 | 4,529,471,000 | 34,808,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 24,434,159 | 3,951,050 | 4,494,663,000 | 1,100,407,000 | $183.95 |
| 02/13/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 20,948,014 | 2,876,536 | 3,880,619,594 | 397,522,594 | $185.25 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 20,483,109 | 2,411,631 | 3,394,256,000 | -88,841,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 18,071,478 | 1,714,071 | 3,483,097,000 | 702,992,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,357,407 | -927,665 | 2,780,105,000 | -37,015,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 17,285,072 | 553,239 | 2,817,120,000 | 309,688,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,731,833 | 171,388 | 2,507,432,000 | -10,419,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,560,445 | -1,923,268 | 2,517,851,000 | 2,515,469,005 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 18,483,713 | -380,935 | 2,381,995 | -2,060,467,005 | $0.13 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 18,864,648 | -1,232,140 | 2,062,849,000 | 582,319,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 20,096,788 | -2,840,955 | 1,480,530,000 | -519,869,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 22,937,743 | 22,937,743 | 2,000,399,000 | 2,000,399,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 22,227,104 | 7,092,351 | 1,911,975,000 | 708,913,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 15,134,753 | 125,568 | 1,203,062,000 | -685,544,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 15,009,185 | -2,679,916 | 1,888,606,000 | 46,464,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 17,689,101 | 1,178,706 | 1,842,142,000 | -196,562,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 16,510,395 | 1,107,622 | 2,038,704,000 | 221,639,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 15,402,773 | 946,619 | 1,817,065,000 | 99,674,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,456,154 | 435,461 | 1,717,391,000 | 142,727,000 | $118.80 |
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