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FMR LLC
> ZGEN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2010 | ZYMOGENETICS INC | ZGEN | 2,917,700 | -2,914,400 | 12,313,000 | -21,105,000 | $4.22 |
| 03/31/2010 | ZYMOGENETICS INC | ZGEN | 5,832,100 | 4,392,200 | 33,418,000 | 24,217,000 | $5.73 |
| 12/31/2009 | ZYMOGENETICS INC | ZGEN | 1,439,900 | 1,180,900 | 9,201,000 | 7,637,000 | $6.39 |
| 09/30/2009 | ZYMOGENETICS INC | ZGEN | 259,000 | 100 | 1,564,000 | 373,000 | $6.04 |
| 06/30/2009 | ZYMOGENETICS INC | ZGEN | 258,900 | 0 | 1,191,000 | 158,000 | $4.60 |
| 03/31/2009 | ZYMOGENETICS INC | ZGEN | 258,900 | 0 | 1,033,000 | 256,000 | $3.99 |
| 12/31/2008 | ZYMOGENETICS INC | ZGEN | 258,900 | -30,600 | 777,000 | -1,151,000 | $3.00 |
| 09/30/2008 | ZYMOGENETICS INC | ZGEN | 289,500 | 289,500 | 1,928,000 | 1,928,000 | $6.66 |
| 06/30/2008 | ZYMOGENETICS INC | ZGEN | 387,423 | 387,423 | 3,262,000 | 3,262,000 | $8.42 |
| 12/31/2007 | ZYMOGENETICS INC | ZGEN | 197,923 | -12,600 | 2,310,000 | -437,000 | $11.67 |
| 09/30/2007 | ZYMOGENETICS INC | ZGEN | 210,523 | 210,523 | 2,747,000 | 2,747,000 | $13.05 |
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