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FIRST CITIZENS BANK & TRUST CO
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 25,804 | 5,908 | 9,080,685,000 | 2,812,054,000 | $351,909.98 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,896 | 8,602 | 6,268,631,000 | 6,265,370,000 | $315,069.91 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,294 | -2,699 | 3,261,000 | -682,000 | $288.74 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,993 | 543 | 3,943,000 | 433,000 | $281.78 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,450 | 483 | 3,510,000 | 662,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,967 | 164 | 2,848,000 | 526,000 | $219.63 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,803 | -1,916 | 2,322,000 | -841,000 | $181.36 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,968 | -751 | 2,816,000 | -347,000 | $201.60 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,719 | 269 | 3,163,000 | -252,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,450 | -484 | 3,415,000 | -649,000 | $236.33 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 14,934 | 1,598 | 4,064,000 | 192,000 | $272.13 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 13,336 | 4,706 | 3,872,000 | 1,818,000 | $290.34 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,630 | 8,630 | 2,054,000 | 2,054,000 | $238.01 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,112 | -2,330 | 681,000 | -320,000 | $218.83 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,442 | 0 | 1,001,000 | 0 | $183.94 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,442 | 570 | 1,001,000 | 194,000 | $183.94 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,872 | 4,872 | 807,000 | 807,000 | $165.64 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -4,798 | 0 | -782,000 | |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,798 | 4,798 | 782,000 | 782,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -2,720 | 0 | -414,000 | |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,720 | 2,720 | 414,000 | 414,000 | $152.21 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -21,926 | 0 | -1,662,000 | |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -21,926 | 0 | -1,662,000 | |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -21,926 | 0 | -1,662,000 | |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -21,926 | 0 | -1,662,000 | |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 21,926 | 2,456 | 1,662,000 | 103,000 | $75.80 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,470 | 0 | 1,559,000 | 743,000 | $80.07 |
| 03/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,470 | 0 | 1,070,000 | 254,000 | $54.96 |
| 12/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,470 | -271 | 816,000 | -287,000 | $41.91 |
| 12/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,470 | -271 | 816,000 | -287,000 | $41.91 |
| 09/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,741 | 1,361 | 1,103,000 | 349,000 | $55.87 |
| 03/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 18,380 | 0 | 754,000 | 144,000 | $41.02 |
| 12/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 18,380 | 0 | 610,000 | -207,000 | $33.19 |
| 09/30/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 18,380 | 18,380 | 817,000 | 817,000 | $44.45 |
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