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MARSHALL WACE, LLP
> XENE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Xenon Pharmaceuticals Inc. | XENE | 2,320,419 | -45,759 | 89,336,133,000 | -3,962,266,000 | $38,500.00 |
| 12/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 2,366,178 | -444,917 | 93,298,399,000 | 93,196,919,000 | $39,430.00 |
| 09/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 2,811,095 | 820,723 | 101,480,000 | 40,933,000 | $36.10 |
| 06/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 1,990,372 | 456,314 | 60,547,000 | 13,650,000 | $30.42 |
| 03/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 1,534,058 | 313,101 | 46,897,000 | 8,754,000 | $30.57 |
| 12/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 1,220,957 | 1,191,154 | 38,143,000 | 37,687,000 | $31.24 |
| 09/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 29,803 | 19,350 | 456,000 | 261,000 | $15.30 |
| 06/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 10,453 | 10,453 | 195,000 | 195,000 | $18.65 |
| 12/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 0 | -37,345 | 0 | -413,000 | |
| 09/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 37,345 | -45,567 | 413,000 | -627,000 | $11.06 |
| 06/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 82,912 | 82,912 | 1,040,000 | 1,040,000 | $12.54 |
| 03/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 0 | -48,606 | 0 | -637,000 | |
| 12/31/2019 | Xenon Pharmaceuticals Inc. | XENE | 48,606 | 48,606 | 637,000 | 637,000 | $13.11 |
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