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MARSHALL WACE, LLP
> KPTI
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Karyopharm Therapeutics Inc. | KPTI | 2,443,997 | 233,774 | 4,374,755,000 | -3,140,004,000 | $1,790.00 |
| 12/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 2,210,223 | 2,051,086 | 7,514,759,000 | 7,513,891,000 | $3,400.00 |
| 09/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 159,137 | 136,137 | 868,000 | 765,000 | $5.45 |
| 06/30/2022 | Karyopharm Therapeutics Inc. | KPTI | 23,000 | 23,000 | 103,000 | 103,000 | $4.48 |
| 03/31/2022 | Karyopharm Therapeutics Inc. | KPTI | 0 | -9,006 | 0 | -57,000 | |
| 12/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 9,006 | 9,006 | 57,000 | 57,000 | $6.33 |
| 03/31/2021 | Karyopharm Therapeutics Inc. | KPTI | 0 | -217,430 | 0 | -3,366,000 | |
| 12/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 217,430 | 198,585 | 3,366,000 | 3,091,000 | $15.48 |
| 09/30/2020 | Karyopharm Therapeutics Inc. | KPTI | 18,845 | 18,845 | 275,000 | 275,000 | $14.59 |
| 03/31/2020 | Karyopharm Therapeutics Inc. | KPTI | 0 | -294,512 | 0 | -5,645,000 | |
| 12/31/2019 | Karyopharm Therapeutics Inc. | KPTI | 294,512 | 294,512 | 5,645,000 | 5,645,000 | $19.17 |
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