| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/15/2023 | Ransley Anna | SVP, CDIO | Grant | Common Stock | 1.1k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Ransley Anna | SVP, CDIO | Grant | Common Stock | 1.2k | $0.00 | $0 | | 08/15/2023 |
| 07/07/2023 | Leneis Melissa | EVP, CHRO | Sale | Common Stock | 4.4k | $195.61 | $869.5k | | 07/05/2023 |
| 07/05/2023 | Leneis Melissa | EVP, CHRO | Payment of Exercise | Common Stock | 2.6k | $194.89 | $502.4k | | 07/05/2023 |
| 06/01/2023 | Henry Charlotte C. | Director | Grant | Common Stock | 672 | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Henry Charlotte C. | Director | Grant | Common Stock | 313 | $191.59 | $60k | | 06/01/2023 |
| 06/01/2023 | Seshasayee Ramaswami | Director | Grant | Common Stock | 672 | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Osborne William H | Director | Grant | Common Stock | 672 | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | FRISBY JEFFRY D | Director | Grant | Common Stock | 672 | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | West Fay | Director | Grant | Common Stock | 672 | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Shannon Michael J | Director | Grant | Common Stock | 672 | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Shannon Michael J | Director | Grant | Common Stock | 313 | $191.59 | $60k | | 06/01/2023 |
| 06/01/2023 | Hinduja Sanjay | Director | Grant | Common Stock | 672 | $0.00 | $0 | | 06/01/2023 |
| 05/31/2023 | Leneis Melissa | EVP, CHRO | Sale | Common Stock | 500 | $190.21 | $95.1k | | 05/31/2023 |
| 05/31/2023 | Leneis Melissa | EVP, CHRO | Exercise | Employee Stock Option (right to buy) | 500 | $142.38 | $71.2k | | 05/31/2023 |
| 05/19/2023 | FRISBY JEFFRY D | Director | Sale | Common Stock | 3.5k | $209.00 | $728.8k | | 05/19/2023 |
| 05/15/2023 | Slinkman David | SVP - Chief Technology Officer | Sale | Common Stock | 736 | $204.20 | $150.3k | | 05/15/2023 |
| 05/15/2023 | Slinkman David | SVP - Chief Technology Officer | Sale | Common Stock | 2.3k | $204.20 | $478k | | 05/15/2023 |
| 05/15/2023 | Slinkman David | SVP - Chief Technology Officer | Sale | Common Stock | 606 | $204.20 | $123.7k | | 05/15/2023 |
| 05/15/2023 | Slinkman David | SVP - Chief Technology Officer | Exercise | Employee Stock Option (right to buy) | 736 | $154.92 | $114k | | 05/15/2023 |
| 05/15/2023 | Slinkman David | SVP - Chief Technology Officer | Exercise | Employee Stock Option (right to buy) | 2.3k | $136.64 | $319.9k | | 05/15/2023 |
| 05/15/2023 | Slinkman David | SVP - Chief Technology Officer | Exercise | Employee Stock Option (right to buy) | 606 | $178.29 | $108k | | 05/15/2023 |
| 05/12/2023 | Leneis Melissa | EVP, CHRO | Sale | Common Stock | 702 | $201.55 | $141.5k | | 05/12/2023 |
| 05/12/2023 | Leneis Melissa | EVP, CHRO | Exercise | Employee Stock Option (right to buy) | 702 | $142.38 | $100k | | 05/12/2023 |
| 05/10/2023 | BERQUIST JOSEPH A | EVP, Chief Commercial Officer | Sale | Common Stock | 560 | $210.00 | $117.6k | | 05/10/2023 |
| 05/10/2023 | BERQUIST JOSEPH A | EVP, Chief Commercial Officer | Sale | Common Stock | 453 | $208.97 | $94.7k | | 05/10/2023 |
| 05/10/2023 | BERQUIST JOSEPH A | EVP, Chief Commercial Officer | Exercise | Employee Stock Option (right to buy) | 922 | $136.64 | $126k | | 05/10/2023 |
| 05/10/2023 | BERQUIST JOSEPH A | EVP, Chief Commercial Officer | Exercise | Employee Stock Option (right to buy) | 560 | $178.29 | $99.8k | | 05/10/2023 |
| 05/10/2023 | BERQUIST JOSEPH A | EVP, Chief Commercial Officer | Sale | Common Stock | 922 | $210.00 | $193.6k | | 05/10/2023 |
| 05/09/2023 | Traub Robert T | SVP, GC & Corp. Sec. | Sale | Common Stock | 1.6k | $205.00 | $320.8k | | 05/09/2023 |
| 05/09/2023 | Traub Robert T | SVP, GC & Corp. Sec. | Sale | Common Stock | 922 | $205.00 | $189k | | 05/09/2023 |
| 05/09/2023 | Traub Robert T | SVP, GC & Corp. Sec. | Sale | Common Stock | 1.2k | $205.00 | $238.4k | | 05/09/2023 |
| 05/09/2023 | Traub Robert T | SVP, GC & Corp. Sec. | Exercise | Employee Stock Option (right to buy) | 1.6k | $154.92 | $242.4k | | 05/09/2023 |
| 05/09/2023 | Traub Robert T | SVP, GC & Corp. Sec. | Exercise | Employee Stock Option (right to buy) | 922 | $136.64 | $126k | | 05/09/2023 |
| 05/09/2023 | Will David | | Sale | Common Stock | 138 | $205.41 | $28.3k | | 05/09/2023 |
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