| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 11/24/2008 | ZUERBLIS KENNETH J | SVP & CFO | Disposition | Stock Options (Right to Buy) | 80k | $42.42 | $3.4M | | 11/24/2008 |
| 11/24/2008 | Powell Andrew Kenneth William | SVP, General Counsel | Disposition | Stock Options (Right to Buy) | 60k | $64.09 | $3.8M | | 11/24/2008 |
| 11/24/2008 | JOHNSON JOHN | CEO | Disposition | Stock Options (Right to Buy) | 350k | $31.90 | $11.2M | | 11/24/2008 |
| 11/24/2008 | JOHNSON JOHN | CEO | Disposition | Restricted Stock Unit | 23.6k | $0.00 | $0 | | 11/24/2008 |
| 11/24/2008 | Rowinsky Eric K | SVP, Chief Medical Officer | Disposition | Stock Options (Right to Buy) | 25k | $34.14 | $853.5k | | 11/24/2008 |
| 11/24/2008 | Rowinsky Eric K | SVP, Chief Medical Officer | Disposition | Stock Options (Right to Buy) | 75k | $42.52 | $3.2M | | 11/24/2008 |
| 11/24/2008 | Rowinsky Eric K | SVP, Chief Medical Officer | Disposition | Restricted Stock Units | 31.3k | $0.00 | $0 | | 11/24/2008 |
| 11/24/2008 | DePinto Joseph I | VP, Commercial Ops | Disposition | Stock Options (Right to Buy) | 45k | $40.09 | $1.8M | | 11/24/2008 |
| 11/24/2008 | Ehmer Bernhard | SVP & Managing Dir., Int'l Ops | Disposition | Stock Options (Right to Buy) | 60k | $43.58 | $2.6M | | 11/24/2008 |
| 11/24/2008 | Schloss David | VP, Human Resources | Disposition | Stock Options (Right to Buy) | 36k | $31.15 | $1.1M | | 11/24/2008 |
| 11/24/2008 | Schloss David | VP, Human Resources | Disposition | Restricted Stock Units | 1000 | $0.00 | $0 | | 11/24/2008 |
| 11/24/2008 | WITTE LARRY | SVP, Research | Disposition | Stock Options (Right to Buy) | 36k | $36.70 | $1.3M | | 11/24/2008 |
| 11/24/2008 | WITTE LARRY | SVP, Research | Disposition | Restricted Stock Units | 3k | $0.00 | $0 | | 11/24/2008 |