| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/31/2023 | Sundaram Senthil Vel | CEO | Purchase | Common Stock | 2.1k | $1.41 | $3k | | 05/31/2023 |
| 05/31/2023 | Vignola Mark J. | CFO | Purchase | Common Stock | 10k | $1.41 | $14.1k | | 05/31/2023 |
| 05/31/2023 | Yoon Seokho Bryan | COO and General Counsel | Purchase | Common Stock | 10k | $1.41 | $14.1k | | 05/31/2023 |
| 12/23/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Common Stock | 137.9k | $7.25 | $1000k | See footnotes | 12/23/2022 |
| 12/23/2022 | GORDON CARL L | 10% Owner | Purchase | Common Stock | 137.9k | $7.25 | $1000k | See footnotes | 12/23/2022 |
| 11/23/2022 | LAV Biosciences Fund V, L.P. | 10% Owner | Sale | Common Stock | 1000k | $5.50 | $5.5M | See footnotes | 11/23/2022 |
| 11/23/2022 | LAV Biosciences Fund V, L.P. | 10% Owner | Sale | Common Stock | 333.3k | $5.50 | $1.8M | See footnotes | 11/23/2022 |
| 11/23/2022 | LAV Biosciences Fund V, L.P. | 10% Owner | Sale | Common Stock | 166.7k | $5.50 | $916.7k | See footnotes | 11/23/2022 |
| 09/07/2022 | Vivo Opportunity, LLC | 10% Owner | Purchase | Common Stock | 600k | $3.60 | $2.2M | By Vivo Opportunity Fund Holdings, L.P. | 09/07/2022 |
| 09/07/2022 | Lu Hongbo | Director | Purchase | Common Stock | 600k | $3.60 | $2.2M | See Footnote | 09/07/2022 |
| 08/16/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Common Stock | 2.5M | $2.42 | $6M | See footnotes | 08/16/2022 |
| 08/16/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Common Stock | 457.4k | $2.42 | $1.1M | See footnotes | 08/16/2022 |
| 08/16/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Common Stock | 762.4k | $2.42 | $1.8M | See footnotes | 08/16/2022 |
| 08/16/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Pre-Funded Warrant | 207.5k | $0.00 | $0 | See footnotes | 08/16/2022 |
| 08/16/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Pre-Funded Warrant | 38.4k | $0.00 | $0 | See footnotes | 08/16/2022 |
| 08/16/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Pre-Funded Warrant | 64k | $0.00 | $0 | See footnotes | 08/16/2022 |
| 08/16/2022 | GORDON CARL L | 10% Owner | Purchase | Pre-Funded Warrant | 207.5k | $0.00 | $0 | See footnotes | 08/16/2022 |
| 08/16/2022 | GORDON CARL L | 10% Owner | Purchase | Pre-Funded Warrant | 38.4k | $0.00 | $0 | See footnotes | 08/16/2022 |
| 08/16/2022 | GORDON CARL L | 10% Owner | Purchase | Pre-Funded Warrant | 64k | $0.00 | $0 | See footnotes | 08/16/2022 |
| 08/16/2022 | GORDON CARL L | 10% Owner | Purchase | Common Stock | 762.4k | $2.42 | $1.8M | See footnotes | 08/16/2022 |
| 08/16/2022 | GORDON CARL L | 10% Owner | Purchase | Common Stock | 457.4k | $2.42 | $1.1M | See footnotes | 08/16/2022 |
| 08/16/2022 | GORDON CARL L | 10% Owner | Purchase | Common Stock | 2.5M | $2.42 | $6M | See footnotes | 08/16/2022 |
| 08/16/2022 | Vivo Opportunity, LLC | 10% Owner | Purchase | Common Stock | 1.5M | $2.42 | $3.6M | By: Vivo Opportunity Fund Holdings, L.P. | 08/12/2022 |
| 08/16/2022 | Vivo Opportunity, LLC | 10% Owner | Purchase | Pre-funded Warrants (right to buy) | 1.5M | $0.00 | $150 | By: Vivo Opportunity Fund Holdings, L.P. | 08/12/2022 |
| 08/16/2022 | Lu Hongbo | Director | Purchase | Common Stock | 1.5M | $2.42 | $3.6M | See Footnote | 08/12/2022 |
| 08/16/2022 | Lu Hongbo | Director | Purchase | Pre-funded Warrants (right to buy) | 1.5M | $0.00 | $150 | See Footnote | 08/12/2022 |
| 08/15/2022 | Vivo Opportunity, LLC | 10% Owner | Purchase | Common Stock | 1.2k | $2.99 | $3.6k | By: Vivo Opportunity Fund Holdings, L.P. | 08/12/2022 |
| 08/15/2022 | Lu Hongbo | Director | Purchase | Common Stock | 1.2k | $2.99 | $3.6k | See Footnote | 08/12/2022 |
| 08/12/2022 | Vivo Opportunity, LLC | 10% Owner | Purchase | Common Stock | 1.1M | $2.98 | $3.3M | By Vivo Opportunity Fund Holdings, L.P. | 08/12/2022 |
| 08/12/2022 | Lu Hongbo | Director | Purchase | Common Stock | 1.1M | $2.98 | $3.3M | See Footnote | 08/12/2022 |
| 07/26/2022 | Tripuraneni Radhika | Director | Grant | Stock Option (Right to Buy) | 64k | $2.13 | $136.3k | | 07/26/2022 |
| 07/01/2022 | Russell Kerry Strong | Chief Medical Officer | Grant | Stock Option (Right to Buy) | 240k | $2.69 | $645.6k | | 07/01/2022 |
| 06/16/2022 | FELLOWS DAVID A | Director | Grant | Stock Option (Right to Buy) | 32k | $1.82 | $58.2k | | 06/16/2022 |
| 06/16/2022 | GORDON CARL L | 10% Owner | Grant | Stock Option (Right to Buy) | 32k | $1.82 | $58.2k | | 06/16/2022 |
| 06/16/2022 | Lu Hongbo | Director | Grant | Stock Option (Right to Buy) | 32k | $1.82 | $58.2k | | 06/16/2022 |
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