| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 28.8k | $12.00 | $345.9k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 28.8k | $0.00 | $0 | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 18.5k | $15.93 | $294.7k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 18.5k | $0.00 | $0 | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 1.2k | $15.93 | $18.7k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 1.2k | $0.00 | $0 | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 18.5k | $11.49 | $212.6k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Disposition | Stock Option (Right to Buy) | 26.4k | $5.20 | $137.1k | | 08/14/2023 |
| 08/14/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 26.4k | $0.00 | $0 | | 08/14/2023 |
| 06/01/2023 | Adicet Bio, Inc. | TORC | Grant | Common Stock | 5.9k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Adicet Bio, Inc. | TORC | Grant | Stock Option (Right to Buy) | 26.4k | $5.20 | $137.1k | | 06/01/2023 |
| 05/08/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 2.8k | $350.00 | $997.5k | | 05/05/2023 |
| 05/05/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 422 | $350.03 | $147.7k | | 05/05/2023 |
| 04/04/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 211 | $314.22 | $66.3k | | 04/04/2023 |
| 04/04/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 94 | $315.66 | $29.7k | | 04/04/2023 |
| 04/04/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 90 | $316.76 | $28.5k | | 04/04/2023 |
| 04/04/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 96 | $317.65 | $30.5k | | 04/04/2023 |
| 04/04/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 31 | $318.68 | $9.9k | | 04/04/2023 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Payment of Exercise | Common Stock | 1.5k | $313.74 | $459.9k | | 03/31/2023 |
| 03/16/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 2.5k | $300.54 | $745.9k | | 03/16/2023 |
| 03/16/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 264 | $301.07 | $79.5k | | 03/16/2023 |
| 02/24/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Payment of Exercise | Common Stock | 4k | $289.12 | $1.1M | | 02/24/2023 |
| 02/17/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Payment of Exercise | Common Stock | 3.8k | $292.85 | $1.1M | | 02/17/2023 |
| 02/13/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Payment of Exercise | Common Stock | 4.3k | $298.26 | $1.3M | | 02/10/2023 |
| 02/13/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 113 | $300.39 | $33.9k | | 02/10/2023 |
| 02/10/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Payment of Exercise | Common Stock | 902 | $294.33 | $265.5k | | 02/10/2023 |
| 11/02/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 56 | $310.10 | $17.4k | | 11/01/2022 |
| 11/02/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 39 | $311.17 | $12.1k | | 11/01/2022 |
| 11/02/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 100 | $312.40 | $31.2k | | 11/01/2022 |
| 11/02/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 81 | $313.37 | $25.4k | | 11/01/2022 |
| 11/02/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 12 | $314.43 | $3.8k | | 11/01/2022 |
| 11/02/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 10 | $315.68 | $3.2k | | 11/01/2022 |
| 11/02/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Sale | Common Stock | 22 | $317.77 | $7k | | 11/01/2022 |
| 11/01/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Payment of Exercise | Common Stock | 768 | $312.84 | $240.3k | | 11/01/2022 |
| 08/01/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | Payment of Exercise | Common Stock | 766 | $276.62 | $211.9k | | 08/01/2022 |
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