| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 10/03/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 9.4k | $44.45 | $417k | | 10/03/2022 |
| 10/03/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 2.8k | $45.47 | $126.9k | | 10/03/2022 |
| 10/03/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 9.7k | $8.22 | $80.1k | | 10/03/2022 |
| 10/03/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 2.4k | $8.22 | $20k | | 10/03/2022 |
| 08/22/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 26.6k | $46.95 | $1.3M | | 08/22/2022 |
| 08/22/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 2.3k | $47.56 | $110.4k | | 08/22/2022 |
| 08/22/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 29k | $24.00 | $695.3k | | 08/22/2022 |
| 04/01/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 6.8k | $49.36 | $333.9k | | 04/01/2022 |
| 04/01/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 7.7k | $49.87 | $384.3k | | 04/01/2022 |
| 04/01/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 14.5k | $24.00 | $347.3k | | 04/01/2022 |
| 03/01/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 4.9k | $40.04 | $195k | | 02/28/2022 |
| 03/01/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 4.9k | $8.22 | $40k | | 02/28/2022 |
| 02/28/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 10k | $24.00 | $241k | | 02/28/2022 |
| 02/28/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 10k | $40.00 | $401.7k | | 02/28/2022 |
| 02/17/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 4.3k | $40.02 | $170.4k | | 02/16/2022 |
| 02/17/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 200 | $24.00 | $4.8k | | 02/16/2022 |
| 02/16/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 4.3k | $24.00 | $102.2k | | 02/16/2022 |
| 02/16/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 4.3k | $40.05 | $170.6k | | 02/16/2022 |
| 01/06/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 1.4k | $39.60 | $55.4k | | 01/06/2022 |
| 01/06/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 4.3k | $40.53 | $174.4k | | 01/06/2022 |
| 01/06/2022 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 424 | $41.23 | $17.5k | | 01/06/2022 |
| 01/06/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 3.7k | $8.22 | $30.3k | | 01/06/2022 |
| 01/06/2022 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 2.4k | $8.22 | $20k | | 01/06/2022 |
| 11/01/2021 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 7.1k | $41.36 | $291.7k | | 11/01/2021 |
| 11/01/2021 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 2.9k | $42.44 | $125k | | 11/01/2021 |
| 11/01/2021 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 6k | $8.22 | $49.7k | | 11/01/2021 |
| 11/01/2021 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 4k | $8.22 | $32.5k | | 11/01/2021 |
| 09/07/2021 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 5k | $37.00 | $185k | | 09/07/2021 |
| 09/07/2021 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 4.1k | $8.22 | $33.6k | | 09/07/2021 |
| 09/07/2021 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 917 | $8.22 | $7.5k | | 09/07/2021 |
| 09/01/2021 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 6.7k | $33.30 | $223k | | 09/01/2021 |
| 09/01/2021 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 3.3k | $34.26 | $113.1k | | 09/01/2021 |
| 09/01/2021 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 10k | $8.22 | $82.2k | | 09/01/2021 |
| 08/27/2021 | Harmony Biosciences Holdings, Inc. | | Sale | Common Stock | 3.4k | $35.18 | $119.6k | | 08/26/2021 |
| 08/27/2021 | Harmony Biosciences Holdings, Inc. | | Exercise | Stock Option | 3.4k | $8.22 | $27.9k | | 08/26/2021 |
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