| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/08/2023 | Mainolfi Nello | CEO | Exercise | Stock Option (Right to Buy) | 12k | $2.08 | $25k | | 08/08/2023 |
| 06/02/2023 | Jacobs Bruce N. | CFO | Exercise | Stock Option (Right to Buy) | 10k | $2.08 | $20.8k | | 06/02/2023 |
| 05/22/2023 | Chadwick Jeremy G | COO | Grant | Common Stock | 33.3k | $0.00 | $0 | | 05/22/2023 |
| 05/22/2023 | Chadwick Jeremy G | COO | Grant | Stock Option (Right to Buy) | 200k | $29.64 | $5.9M | | 05/22/2023 |
| 01/12/2023 | BVF PARTNERS L P/IL | Director | Purchase | | 15.9k | $31.24 | $497.1k | | 01/11/2023 |
| 01/12/2023 | Booth Bruce | Director | Sale | Common Stock | 77.1k | $30.29 | $2.3M | See footnote | 01/11/2023 |
| 01/12/2023 | Booth Bruce | Director | Sale | Common Stock | 21.6k | $30.29 | $654k | See footnote | 01/11/2023 |
| 01/12/2023 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 77.1k | $30.29 | $2.3M | | 01/11/2023 |
| 01/12/2023 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 21.6k | $30.29 | $654k | See footnote | 01/11/2023 |
| 01/12/2023 | BVF PARTNERS L P/IL | Director | Purchase | | 3k | $31.24 | $93.3k | | 01/11/2023 |
| 01/11/2023 | BVF PARTNERS L P/IL | Director | Purchase | | 11k | $29.89 | $327.6k | | 01/11/2023 |
| 01/11/2023 | BVF PARTNERS L P/IL | Director | Purchase | | 11.1k | $29.89 | $333.2k | | 01/11/2023 |
| 01/11/2023 | Booth Bruce | Director | Sale | Common Stock | 21.7k | $29.96 | $649.6k | See footnote | 01/11/2023 |
| 01/11/2023 | Booth Bruce | Director | Sale | Common Stock | 6.1k | $29.96 | $181.9k | See footnote | 01/11/2023 |
| 01/11/2023 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 21.7k | $29.96 | $649.6k | | 01/11/2023 |
| 01/11/2023 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 6.1k | $29.96 | $181.9k | See footnote | 01/11/2023 |
| 01/03/2023 | Chiniara Ellen | Chief Legal Officer | Grant | Stock Option (Right to Buy) | 225k | $24.84 | $5.6M | | 01/03/2023 |
| 01/03/2023 | Chiniara Ellen | Chief Legal Officer | Grant | Common Stock | 37.5k | $0.00 | $0 | | 01/03/2023 |
| 12/15/2022 | Booth Bruce | Director | Sale | Common Stock | 2.6k | $30.00 | $76.8k | See footnote | 12/14/2022 |
| 12/15/2022 | Booth Bruce | Director | Sale | Common Stock | 717 | $30.00 | $21.5k | See footnote | 12/14/2022 |
| 12/15/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 2.6k | $30.00 | $76.8k | | 12/14/2022 |
| 12/15/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 717 | $30.00 | $21.5k | See footnote | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 112.8k | $30.28 | $3.4M | | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 101.2k | $31.44 | $3.2M | | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 54.7k | $32.33 | $1.8M | | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 14k | $33.34 | $466.7k | | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 13.3k | $34.02 | $453.7k | | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 31.6k | $30.28 | $956.4k | See footnote | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 28.3k | $31.44 | $890.7k | See footnote | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 15.3k | $32.33 | $495.4k | See footnote | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 3.9k | $33.34 | $130.7k | See footnote | 12/14/2022 |
| 12/14/2022 | Atlas Venture Fund X, L.P. | 10% Owner | Sale | Common Stock | 3.7k | $34.02 | $127k | See footnote | 12/14/2022 |
| 12/14/2022 | Booth Bruce | Director | Sale | Common Stock | 112.8k | $30.28 | $3.4M | See footnote | 12/14/2022 |
| 12/14/2022 | Booth Bruce | Director | Sale | Common Stock | 101.2k | $31.44 | $3.2M | See footnote | 12/14/2022 |
| 12/14/2022 | Booth Bruce | Director | Sale | Common Stock | 54.7k | $32.33 | $1.8M | See footnote | 12/14/2022 |
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