| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 20.5k | $2.17 | $44.6k | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 21k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 8.8k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 26.1k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 15.1k | $2.85 | $42.9k | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 11.1k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 21k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 8.8k | $0.00 | $0 | | 02/28/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 78.3k | $0.00 | $0 | | 02/10/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 234.9k | $3.20 | $751.6k | | 02/10/2022 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 21k | $0.00 | $0 | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 11.1k | $0.00 | $0 | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 5.1k | $0.00 | $0 | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 1.5k | $0.00 | $0 | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 14.9k | $7.19 | $106.8k | | 02/28/2021 |
| 02/11/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 26.2k | $0.00 | $0 | | 02/11/2021 |
| 02/11/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 78.8k | $8.38 | $660k | | 02/11/2021 |
| 04/22/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Common Stock | 19.9k | $0.00 | $0 | | 04/22/2020 |
| 04/22/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 6.4k | $1.96 | $12.5k | | 04/22/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 11.1k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 5.1k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 1.5k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 2.5k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 6.9k | $2.77 | $19.2k | | 02/28/2020 |
| 02/06/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 189.3k | $3.31 | $626.5k | | 02/06/2020 |
| 02/06/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 63.1k | $0.00 | $0 | | 02/06/2020 |