| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.6k | $185.54 | $295.6k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 658 | $184.70 | $121.5k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 944 | $186.39 | $176k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 86 | $187.37 | $16.1k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 15 | $188.40 | $2.8k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 164 | $189.31 | $31k | | 08/03/2023 |
| 08/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.1k | $0.00 | $0 | | 08/03/2023 |
| 08/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 4.5k | $0.00 | $0 | | 08/03/2023 |
| 06/14/2023 | Homology Medicines, Inc. | FIXX | Grant | Option (Right to Buy) | 23k | $1.03 | $23.7k | | 06/14/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 68 | $197.08 | $13.4k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 81 | $193.18 | $15.6k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 372 | $193.93 | $72.1k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 414 | $194.94 | $80.7k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 42 | $195.65 | $8.2k | | 04/26/2023 |
| 04/26/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.3k | $0.00 | $0 | | 04/26/2023 |
| 02/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Restricted Stock Units | 5.7k | $0.00 | $0 | | 02/27/2023 |
| 02/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 11.8k | $190.01 | $2.3M | | 02/27/2023 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 173 | $210.50 | $36.4k | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 146 | $209.88 | $30.6k | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 162 | $209.83 | $34k | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 4.6k | $189.76 | $867.8k | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.1k | $0.00 | $0 | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.7k | $0.00 | $0 | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 4.5k | $0.00 | $0 | | 08/03/2022 |
| 06/15/2022 | Homology Medicines, Inc. | FIXX | Grant | Option (Right to Buy) | 18k | $1.88 | $33.8k | | 06/15/2022 |
| 02/23/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 18.4k | $147.47 | $2.7M | | 02/23/2022 |
| 06/17/2021 | Homology Medicines, Inc. | FIXX | Grant | Option (Right to Buy) | 18k | $7.26 | $130.7k | | 06/17/2021 |
| 04/20/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 1.3k | $131.75 | $175.6k | | 10/10/2019 |
| 04/20/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 50 | $134.49 | $6.7k | | 10/10/2019 |
| 04/19/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 4.5k | $0.00 | $0 | | 10/10/2019 |
| 02/24/2021 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 23.2k | $151.59 | $3.5M | | 02/24/2021 |
| 07/21/2020 | Homology Medicines, Inc. | FIXX | Grant | Option (Right to Buy) | 36k | $16.48 | $593.3k | | 07/21/2020 |
| 02/26/2020 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 24.6k | $118.05 | $2.9M | | 01/03/2020 |
| 01/03/2020 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Other (acquisition) | Common Stock | 19 | $0.00 | $0 | by Managed Account | 01/03/2020 |
| 10/10/2019 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Other (acquisition) | Common Stock | 38 | $0.00 | $0 | by Managed Account | 10/10/2019 |