| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/06/2023 | Reneo Pharmaceuticals, Inc. | RPHM | Grant | Stock Option (right to buy) | 17.5k | $9.01 | $157.7k | | 06/06/2023 |
| 05/25/2023 | SPRUCE BIOSCIENCES, INC. | SPRB | Grant | Stock Option (Right to Buy) | 30k | $2.26 | $67.8k | | 05/25/2023 |
| 05/08/2023 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 125k | $8.00 | $1000k | By RiverVest Venture Fund IV, L.P. | 05/08/2023 |
| 02/16/2023 | SPRUCE BIOSCIENCES, INC. | SPRB | Purchase | Common Stock | 630.4k | $3.17 | $2M | By RiverVest Venture Fund IV, L.P. | 02/16/2023 |
| 02/16/2023 | SPRUCE BIOSCIENCES, INC. | SPRB | Purchase | Common Stock Warrant (Right to Buy) | 472.8k | $3.96 | $1.9M | By RiverVest Venture Fund IV, L.P. | 02/16/2023 |
| 11/15/2022 | Mirum Pharmaceuticals, Inc. | MIRM | Sale | Common Stock | 93.8k | $19.69 | $1.8M | By RiverVest Venture Fund IV, L.P. | 11/11/2022 |
| 11/14/2022 | Mirum Pharmaceuticals, Inc. | MIRM | Sale | Common Stock | 32.1k | $19.60 | $629.4k | By RiverVest Venture Fund IV, L.P. | 11/11/2022 |
| 11/11/2022 | Mirum Pharmaceuticals, Inc. | MIRM | Sale | Common Stock | 174.1k | $19.99 | $3.5M | By RiverVest Venture Fund IV, L.P. | 11/11/2022 |
| 06/02/2022 | Mirum Pharmaceuticals, Inc. | MIRM | Grant | Stock Option (right to buy) | 17k | $23.51 | $399.7k | | 06/02/2022 |
| 06/01/2022 | Reneo Pharmaceuticals, Inc. | RPHM | Grant | Stock Option (right to buy) | 17.5k | $2.09 | $36.6k | | 06/01/2022 |
| 05/25/2022 | SPRUCE BIOSCIENCES, INC. | SPRB | Grant | Stock Option (Right to Buy) | 22.5k | $1.32 | $29.7k | | 05/25/2022 |
| 06/04/2021 | Mirum Pharmaceuticals, Inc. | MIRM | Grant | Stock Option (right to buy) | 17k | $16.88 | $287k | | 06/04/2021 |
| 05/20/2021 | SPRUCE BIOSCIENCES, INC. | SPRB | Grant | Stock Option (Right to Buy) | 10k | $15.24 | $152.4k | | 05/20/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Conversion | Common Stock | 1M | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 04/13/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Conversion | Common Stock | 829.1k | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 04/13/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Purchase | Common Stock | 200k | $15.00 | $3M | By RiverVest Venture Fund IV, L.P. | 04/13/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Conversion | Series A Preferred Stock | 4.6M | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 04/13/2021 |
| 04/13/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Conversion | Series B Preferred Stock | 3.7M | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 04/13/2021 |
| 04/08/2021 | Reneo Pharmaceuticals, Inc. | RPHM | Grant | Stock Option (right to buy) | 14k | $15.00 | $210k | | 04/08/2021 |
| 10/14/2020 | SPRUCE BIOSCIENCES, INC. | SPRB | Conversion | Series B Preferred Stock | 2.9M | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 10/14/2020 |
| 10/14/2020 | SPRUCE BIOSCIENCES, INC. | SPRB | Purchase | Common Stock | 250k | $15.00 | $3.8M | By RiverVest Venture Fund IV, L.P. | 10/14/2020 |
| 10/14/2020 | SPRUCE BIOSCIENCES, INC. | SPRB | Conversion | Common Stock | 445.9k | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 10/14/2020 |
| 06/11/2020 | Mirum Pharmaceuticals, Inc. | MIRM | Grant | Stock Option (right to buy) | 17k | $16.71 | $284.1k | | 06/11/2020 |
| 07/22/2019 | Mirum Pharmaceuticals, Inc. | MIRM | Conversion | Series A Preferred Stock | 12M | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 07/22/2019 |
| 07/22/2019 | Mirum Pharmaceuticals, Inc. | MIRM | Purchase | Common Stock | 300k | $15.00 | $4.5M | By RiverVest Venture Fund IV, L.P. | 07/22/2019 |
| 07/22/2019 | Mirum Pharmaceuticals, Inc. | MIRM | Conversion | Common Stock | 1.5M | $0.00 | $0 | By RiverVest Venture Fund IV, L.P. | 07/22/2019 |