| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 12/30/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 61.8k | $0.27 | $16.7k | Through Deerfield Healthcare Innovations Fund, L.P. | 12/28/2022 |
| 12/30/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 15.2k | $0.27 | $4.1k | Through Deerfield Partners, L.P. | 12/28/2022 |
| 12/29/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 63.1k | $0.26 | $16.4k | Through Deerfield Healthcare Innovations Fund, L.P. | 12/28/2022 |
| 12/29/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 63.1k | $0.26 | $16.4k | Through Deerfield Private Design Fund III, L.P. | 12/28/2022 |
| 12/29/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 15.5k | $0.26 | $4k | Through Deerfield Partners, L.P. | 12/28/2022 |
| 12/28/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 24.8k | $0.25 | $6.2k | Through Deerfield Healthcare Innovations Fund, L.P. | 12/28/2022 |
| 12/28/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 6.1k | $0.25 | $1.5k | Through Deerfield Partners, L.P. | 12/28/2022 |
| 12/21/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 6.1k | $0.30 | $1.8k | Through Deerfield Healthcare Innovations Fund, L.P. | 12/19/2022 |
| 12/21/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 6.1k | $0.30 | $1.8k | Through Deerfield Private Design Fund III, L.P. | 12/19/2022 |
| 12/21/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 1.5k | $0.30 | $453.9 | Through Deerfield Partners, L.P. | 12/19/2022 |
| 12/20/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 6.6k | $0.31 | $2k | Through Deerfield Healthcare Innovations Fund, L.P. | 12/19/2022 |
| 12/20/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 1.6k | $0.31 | $501 | Through Deerfield Partners, L.P. | 12/19/2022 |
| 12/19/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 44.4k | $0.29 | $12.9k | Through Deerfield Healthcare Innovations Fund, L.P. | 12/19/2022 |
| 12/19/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 10.9k | $0.29 | $3.2k | Through Deerfield Partners, L.P. | 12/19/2022 |
| 12/15/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 1.4k | $0.39 | $536.2 | Through Deerfield Healthcare Innovations Fund, L.P. | 12/13/2022 |
| 12/15/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 339 | $0.39 | $132.2 | Through Deerfield Partners, L.P. | 12/13/2022 |
| 12/14/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 3.8k | $0.38 | $1.5k | Through Deerfield Healthcare Innovations Fund, L.P. | 12/13/2022 |
| 12/14/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 3.8k | $0.38 | $1.5k | Through Deerfield Private Design Fund III, L.P. | 12/13/2022 |
| 12/14/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 943 | $0.38 | $358.3 | Through Deerfield Partners, L.P. | 12/13/2022 |
| 12/13/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 934 | $0.41 | $382.9 | Through Deerfield Healthcare Innovations Fund, L.P. | 12/13/2022 |
| 12/13/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 933 | $0.41 | $382.5 | Through Deerfield Private Design Fund III, L.P. | 12/13/2022 |
| 12/13/2022 | Flynn James E | 10% Owner | Sale | Common Stock | 230 | $0.41 | $94.3 | Through Deerfield Partners, L.P. | 12/13/2022 |
| 11/01/2022 | Harbin Stephen | COO and Chief of Staff | Grant | Stock Option (right to buy) | 150k | $0.67 | $100.5k | | 11/01/2022 |
| 06/23/2022 | Nam Spencer | Director | Grant | Stock Option (right to buy) | 12.5k | $1.60 | $20k | | 06/23/2022 |
| 06/23/2022 | Rubin Eric | Director | Grant | Stock Option (right to buy) | 12.5k | $1.60 | $20k | | 06/23/2022 |
| 06/23/2022 | Yanni Barbara | Director | Grant | Stock Option (right to buy) | 12.5k | $1.60 | $20k | | 06/23/2022 |
| 06/23/2022 | EVNIN LUKE | Director | Grant | Stock Option (right to buy) | 12.5k | $1.60 | $20k | | 06/23/2022 |
| 06/23/2022 | Canute Scott A | Director | Grant | Stock Option (right to buy) | 12.5k | $1.60 | $20k | | 06/23/2022 |
| 06/23/2022 | Fenton Mary Kay | Director | Grant | Stock Option (right to buy) | 12.5k | $1.60 | $20k | | 06/23/2022 |
| 06/23/2022 | Finer Mitchell H. | Director | Grant | Stock Option (right to buy) | 12.5k | $1.60 | $20k | | 06/23/2022 |
| 06/22/2022 | FAMBROUGH DOUGLAS | Director | Grant | Stock Option (right to buy) | 25k | $1.50 | $37.5k | | 06/22/2022 |
| 05/25/2022 | Wanstall Rick | CFO and Treasurer | Purchase | Common Stock | 3.8k | $1.20 | $4.5k | | 05/25/2022 |
| 05/20/2022 | Wanstall Rick | CFO and Treasurer | Purchase | Common Stock | 1.6k | $1.20 | $1.9k | | 05/20/2022 |
| 05/19/2022 | Wanstall Rick | CFO and Treasurer | Purchase | Common Stock | 5k | $1.29 | $6.4k | | 05/17/2022 |
| 05/17/2022 | Wanstall Rick | CFO and Treasurer | Purchase | Common Stock | 1 | $1.20 | $1.2 | | 05/17/2022 |
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