| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/04/2008 | Karobath Manfred E | Director | Other | Common Stock - $.01 par value | 135.8k | $0.00 | $0 | | 01/04/2008 |
| 01/04/2008 | Karobath Manfred E | Director | Other | Stock Option (Right to Buy) | 3.8k | $1.15 | $4.3k | | 01/04/2008 |
| 01/04/2008 | Karobath Manfred E | Director | Other | Stock Option (Right to Buy) | 4.5k | $1.15 | $5.2k | | 01/04/2008 |
| 01/04/2008 | Karobath Manfred E | Director | Other | Stock Warrant (Right to Buy) | 11.4k | $5.64 | $64.1k | | 01/04/2008 |
| 01/04/2008 | Abdalian Charles H Jr | SVP, Finance and CFO | Other | Stock Option (Right to Buy) | 8.7k | $1.15 | $10k | | 01/04/2008 |
| 01/04/2008 | Langlois Patrick | Director | Other | Stock Option (Right to Buy) | 21.8k | $1.15 | $25.1k | | 01/04/2008 |
| 01/04/2008 | Massari Ferdinand E | Sr. VP of Drug Development | Other | Stock Option (Right to Buy) | 65k | $3.13 | $203.4k | | 01/04/2008 |
| 01/04/2008 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Other | Common Stock - $.01 par value | 545.6k | $0.00 | $0 | | 01/04/2008 |
| 01/04/2008 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Other | Common Stock - $.01 par value | 5.2k | $0.00 | $0 | Trustee of Trust | 01/04/2008 |
| 01/04/2008 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Other | Stock Option (Right to Buy) | 153.7k | $1.15 | $176.7k | | 01/04/2008 |
| 01/04/2008 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Other | Stock Option (Right to Buy) | 13.6k | $1.15 | $15.7k | | 01/04/2008 |
| 01/04/2008 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Other | Stock Option (Right to Buy) | 94.8k | $1.15 | $109k | | 01/04/2008 |
| 01/04/2008 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Other | Stock Option (Right to Buy) | 55k | $3.13 | $172.2k | | 01/04/2008 |
| 01/04/2008 | BATE KENNETH | Director | Other | Stock Option (Right to Buy) | 21.8k | $1.15 | $25.1k | | 01/04/2008 |
| 01/04/2008 | HUGIN ROBERT J | Director | Other | Stock Option (Right to Boy) | 21.8k | $1.15 | $25.1k | | 01/04/2008 |
| 01/04/2008 | Bratzler Robert L | President and CEO | Other | Common Stock - $.01 par value | 308.7k | $0.00 | $0 | | 01/04/2008 |
| 01/04/2008 | Bratzler Robert L | President and CEO | Other | Common Stock - $.01 par value | 150.7k | $0.00 | $0 | Indirect control of Blueberry Lane Trust | 01/04/2008 |
| 01/04/2008 | Bratzler Robert L | President and CEO | Other | Stock Option (Right to Buy) | 357k | $1.15 | $410.5k | | 01/04/2008 |
| 01/04/2008 | Bratzler Robert L | President and CEO | Other | Stock Option (Right to Buy) | 168.3k | $1.15 | $193.5k | | 01/04/2008 |
| 01/04/2008 | Bratzler Robert L | President and CEO | Other | Stock Option (Right to Buy) | 70k | $3.13 | $219.1k | | 01/04/2008 |
| 01/04/2008 | Abdalian Charles H Jr | SVP, Finance and CFO | Other | Stock Option (Right to Buy) | 52.4k | $1.15 | $60.3k | | 01/04/2008 |
| 01/04/2008 | Abdalian Charles H Jr | SVP, Finance and CFO | Other | Stock Option (Right to Buy) | 58.1k | $1.15 | $66.8k | | 01/04/2008 |
| 01/04/2008 | Abdalian Charles H Jr | SVP, Finance and CFO | Other | Stock Option (Right to Buy) | 40k | $3.13 | $125.2k | | 01/04/2008 |
| 12/06/2007 | Karobath Manfred E | Director | Sale | Common Stock | 27k | $7.93 | $214.1k | | 12/06/2007 |
| 09/18/2007 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Grant | Stock Options (right to buy) | 55k | $3.13 | $172.2k | | 09/18/2007 |
| 09/18/2007 | Bratzler Robert L | President and CEO | Grant | Stock Options (right to buy) | 70k | $3.13 | $219.1k | | 09/18/2007 |
| 09/18/2007 | Abdalian Charles H Jr | SVP, Finance and CFO | Grant | Stock Options (right to buy) | 40k | $3.13 | $125.2k | | 09/18/2007 |
| 09/18/2007 | Massari Ferdinand E | Sr. VP of Drug Development | Grant | Stock Options (right to buy) | 65k | $3.13 | $203.4k | | 09/18/2007 |
| 08/29/2007 | Krieg Arthur M | SVP, R & D, Chief Scien. Off. | Sale | Common Stock | 21.1k | $1.89 | $39.8k | | 08/29/2007 |
| 06/14/2007 | BATE KENNETH | Director | Grant | | 5.5k | $8.02 | $43.8k | | 06/14/2007 |
| 06/14/2007 | Langlois Patrick | Director | Grant | | 5.5k | $8.02 | $43.8k | | 06/14/2007 |
| 06/14/2007 | Karobath Manfred E | Director | Grant | | 5.5k | $8.02 | $43.8k | | 06/14/2007 |
| 06/14/2007 | HUGIN ROBERT J | Director | Grant | | 5.5k | $8.02 | $43.8k | | 06/14/2007 |
| 05/11/2007 | THOMAS JAMES E | Director | Purchase | Common Stock | 60k | $8.66 | $519.6k | Please see Footnote 1 | 05/10/2007 |
| 05/10/2007 | THOMAS JAMES E | Director | Purchase | Common Stock | 100k | $8.68 | $868k | Please see Footnote 1 | 05/10/2007 |
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