| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/22/2022 | BRYNJELSEN SEAN | CEO | Purchase | Common Stock | 10k | $2.10 | $21k | | 09/22/2022 |
| 07/12/2022 | BRYNJELSEN SEAN | CEO | Grant | Restricted Stock Units | 110k | $0.00 | $0 | | 07/12/2022 |
| 07/12/2022 | Gruber James R. | CFO | Grant | Restricted Stock Units | 40k | $0.00 | $0 | | 07/12/2022 |
| 02/07/2022 | Adams Jennifer McKie | Director | Grant | Stock Option (Right to buy) | 50k | $3.78 | $189k | | 02/07/2022 |
| 02/07/2022 | Troutman William Wilson | CFO and Secretary | Grant | Stock Option (Right to buy) | 15k | $3.78 | $56.7k | | 02/07/2022 |
| 02/07/2022 | BRYNJELSEN SEAN | CEO | Grant | Stock Option(Right to buy) | 416.5k | $3.78 | $1.6M | | 02/07/2022 |
| 02/07/2022 | CASAMENTO CHARLES J | Director | Grant | Stock Option (Right to buy) | 50k | $3.78 | $189k | | 02/07/2022 |
| 02/07/2022 | RIEDEL NORBERT G | Director | Grant | Stock Option (Right to buy) | 50k | $3.78 | $189k | | 02/07/2022 |
| 11/17/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 25k | $4.67 | $116.7k | By Opaleye, L.P. | 11/17/2021 |
| 11/16/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 11.5k | $4.86 | $55.9k | By Opaleye, L.P. | 11/15/2021 |
| 11/16/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 938 | $4.86 | $4.6k | By Managed Account | 11/15/2021 |
| 11/15/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 2.5k | $4.80 | $12k | By Opaleye, L.P. | 11/15/2021 |
| 11/15/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 500 | $4.80 | $2.4k | By Managed Account | 11/15/2021 |
| 11/08/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 50k | $6.10 | $305k | By Opaleye, L.P. | 11/05/2021 |
| 11/08/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 2.7k | $6.10 | $16.2k | By Managed Account | 11/05/2021 |
| 11/05/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 159.3k | $6.30 | $1M | By Opaleye, L.P. | 11/05/2021 |
| 11/05/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 8.4k | $6.30 | $52.9k | By Managed Account | 11/05/2021 |
| 11/04/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 81.7k | $6.44 | $525.9k | By Opaleye, L.P. | 11/03/2021 |
| 11/04/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 4k | $6.44 | $25.7k | By Managed Account | 11/03/2021 |
| 11/03/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 110k | $6.53 | $718.4k | By Opaleye, L.P. | 11/03/2021 |
| 11/03/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 6.5k | $6.53 | $42.5k | By Managed Account | 11/03/2021 |
| 10/12/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 82.5k | $5.06 | $417.2k | By Opaleye, L.P. | 10/08/2021 |
| 10/12/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 4.8k | $5.06 | $24.3k | By Managed Account | 10/08/2021 |
| 10/11/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 32.5k | $5.01 | $162.7k | By Opaleye, L.P. | 10/08/2021 |
| 10/11/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 1.6k | $5.01 | $8k | By Managed Account | 10/08/2021 |
| 10/08/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 41k | $5.00 | $205k | By Opaleye, L.P. | 10/08/2021 |
| 10/08/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 2.7k | $5.00 | $13.5k | By Managed Account | 10/08/2021 |
| 08/20/2021 | BRYNJELSEN SEAN | CEO | Purchase | Common Stock | 10k | $4.32 | $43.2k | | 08/20/2021 |
| 08/20/2021 | Troutman William Wilson | CFO and Secretary | Purchase | Common Stock | 5k | $4.43 | $22.2k | | 08/20/2021 |
| 08/06/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 330k | $5.84 | $1.9M | By Opaleye, L.P. | 08/04/2021 |
| 08/06/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 15k | $5.84 | $87.6k | By Managed Account | 08/04/2021 |
| 08/05/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 150k | $5.85 | $878k | By Opaleye, L.P. | 08/04/2021 |
| 08/05/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 5.5k | $5.85 | $32.2k | By Managed Account | 08/04/2021 |
| 08/04/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 100k | $5.75 | $575.1k | By Opaleye, L.P. | 08/04/2021 |
| 08/04/2021 | Opaleye Management Inc. | 10% Owner | Sale | Common Stock, par value $0.001 per share | 4k | $5.75 | $23k | By Managed Account | 08/04/2021 |
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