| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/12/2023 | Praxis Precision Medicines, Inc. | PRAX | Grant | Common Stock | 11.7k | $0.88 | $10.3k | | 05/12/2023 |
| 03/23/2023 | Praxis Precision Medicines, Inc. | PRAX | Purchase | Common Stock | 35k | $0.86 | $30.2k | Held by spouse | 03/23/2023 |
| 03/23/2023 | Praxis Precision Medicines, Inc. | PRAX | Purchase | Common Stock | 35k | $0.86 | $30.2k | | 03/23/2023 |
| 01/12/2023 | Praxis Precision Medicines, Inc. | PRAX | Grant | Stock Option (Right to Buy) | 214k | $2.96 | $633.4k | | 01/12/2023 |
| 11/14/2022 | Praxis Precision Medicines, Inc. | PRAX | Grant | Common Stock | 2.1k | $1.81 | $3.8k | | 11/14/2022 |
| 08/25/2022 | Aeglea BioTherapeutics, Inc. | AGLE | Purchase | Common Stock | 90k | $0.56 | $50.5k | | 08/25/2022 |
| 06/22/2022 | Praxis Precision Medicines, Inc. | PRAX | Grant | Stock Option (Right to Buy) | 100k | $2.12 | $212k | | 06/22/2022 |
| 06/08/2022 | Praxis Precision Medicines, Inc. | PRAX | Purchase | Common Stock | 27k | $1.85 | $49.9k | | 06/08/2022 |
| 06/07/2022 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Director Stock Option (right to buy) | 43k | $0.73 | $31.4k | | 06/07/2022 |
| 01/07/2022 | Praxis Precision Medicines, Inc. | PRAX | Grant | Common Stock | 74k | $0.00 | $0 | | 01/07/2022 |
| 01/07/2022 | Praxis Precision Medicines, Inc. | PRAX | Grant | Stock Option (Right to Buy) | 259k | $18.11 | $4.7M | | 01/07/2022 |
| 06/18/2021 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Director Stock Option (right to buy) | 60k | $6.44 | $386.4k | | 06/18/2021 |
| 02/12/2021 | Praxis Precision Medicines, Inc. | PRAX | Grant | Common Stock | 52.8k | $0.00 | $0 | | 02/12/2021 |
| 02/12/2021 | Praxis Precision Medicines, Inc. | PRAX | Grant | Stock Option (Right to Buy) | 184.8k | $52.53 | $9.7M | | 02/12/2021 |
| 11/10/2020 | Praxis Precision Medicines, Inc. | PRAX | Purchase | Common Stock | 3.8k | $26.08 | $100.3k | | 11/10/2020 |
| 10/20/2020 | Praxis Precision Medicines, Inc. | PRAX | Conversion | Common Stock | 20.6k | $0.00 | $0 | | 10/20/2020 |
| 10/20/2020 | Praxis Precision Medicines, Inc. | PRAX | Conversion | Series C -1 Preferred Stock | 44.1k | $0.00 | $0 | | 10/20/2020 |
| 02/10/2020 | PTC THERAPEUTICS, INC. | PTCT | Exercise | Stock Option (Right To Buy) | 625 | $12.92 | $8.1k | By Spouse | 02/10/2020 |
| 02/10/2020 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 625 | $53.92 | $33.7k | By Spouse | 02/10/2020 |
| 01/29/2020 | PTC THERAPEUTICS, INC. | PTCT | Grant | Stock Option (Right To Buy) | 93.5k | $51.16 | $4.8M | | 01/29/2020 |
| 01/29/2020 | PTC THERAPEUTICS, INC. | PTCT | Grant | Stock Option (Right To Buy) | 4.2k | $51.16 | $213.3k | By Spouse | 01/29/2020 |
| 01/29/2020 | PTC THERAPEUTICS, INC. | PTCT | Grant | Common Stock | 1.7k | $0.00 | $0 | By Spouse | 01/29/2020 |
| 01/29/2020 | PTC THERAPEUTICS, INC. | PTCT | Grant | Common Stock | 12.6k | $0.00 | $0 | | 01/29/2020 |
| 01/23/2020 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 154 | $53.25 | $8.2k | By Spouse | 01/23/2020 |
| 01/06/2020 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 86 | $48.17 | $4.1k | By Spouse | 12/30/2019 |
| 12/30/2019 | PTC THERAPEUTICS, INC. | PTCT | Gift | Common Stock | 1000 | $0.00 | $0 | | 12/30/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Exercise | Stock Option (Right To Buy) | 15.9k | $11.23 | $178.3k | | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Exercise | Stock Option (Right To Buy) | 30k | $18.01 | $540.3k | | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Exercise | Stock Option (Right To Buy) | 6.2k | $12.92 | $80.8k | By Spouse | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 6k | $48.32 | $289.9k | | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 14.8k | $49.14 | $728k | | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 8.7k | $48.32 | $421.8k | | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 21.3k | $49.14 | $1M | | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 8.9k | $48.58 | $431.2k | | 12/23/2019 |
| 12/23/2019 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 7k | $49.32 | $345.4k | | 12/23/2019 |
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