| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (right to buy) | 750 | $26.40 | $19.8k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (right to buy) | 18.1k | $13.98 | $252.5k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (right to buy) | 6k | $18.11 | $108.7k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (right to buy) | 1.9k | $82.40 | $159.9k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (right to buy) | 625 | $45.20 | $28.2k | | 07/01/2022 |
| 07/01/2022 | Sierra Oncology, Inc. | SRRA | Disposition | Stock Option (right to buy) | 625 | $130.80 | $81.8k | | 07/01/2022 |
| 06/08/2021 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (Right To Buy) | 6k | $18.11 | $108.7k | | 06/08/2021 |
| 06/09/2020 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (right to buy) | 18.1k | $13.98 | $252.5k | | 06/09/2020 |
| 06/11/2019 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (right to buy) | 30k | $0.66 | $19.8k | | 06/11/2019 |
| 06/12/2018 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (right to buy) | 25k | $3.27 | $81.8k | | 06/12/2018 |
| 06/13/2017 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (right to buy) | 25k | $1.13 | $28.2k | | 06/13/2017 |
| 11/01/2016 | Tobira Therapeutics, Inc. | TBRA | Disposition | Employee Stock Option (Right to Buy) | 17.8k | $7.91 | $140.6k | | 11/01/2016 |
| 11/01/2016 | Tobira Therapeutics, Inc. | TBRA | Disposition | Employee Stock Option (Right to Buy) | 15.5k | $16.52 | $256.1k | | 11/01/2016 |
| 11/01/2016 | Tobira Therapeutics, Inc. | TBRA | Disposition | Employee Stock Option (Right to Buy) | 13.5k | $8.13 | $110.1k | | 11/01/2016 |
| 06/09/2016 | Sierra Oncology, Inc. | SRRA | Grant | Stock Option (right to buy) | 77.7k | $2.06 | $160k | | 06/09/2016 |
| 01/12/2016 | Tobira Therapeutics, Inc. | TBRA | Grant | Stock Options (right to buy) | 17.8k | $7.91 | $140.6k | | 01/12/2016 |
| 07/09/2015 | Tobira Therapeutics, Inc. | TBRA | Grant | Stock Options (right to buy) | 15.5k | $16.52 | $256.1k | | 07/09/2015 |
| 05/04/2015 | Tobira Therapeutics, Inc. | TBRA | Grant | Stock Options (right to buy) | 13.5k | $0.00 | $0 | | 05/04/2015 |
| 04/30/2013 | HUMANIGEN, INC | HGEN | Grant | Stock Option (right to buy) | 60k | $6.00 | $360k | | 04/30/2013 |
| 09/01/2011 | BIOMARIN PHARMACEUTICAL INC | BMRN | Exercise | Common Stock | 2.5k | $14.39 | $36k | | 09/01/2011 |
| 09/01/2011 | BIOMARIN PHARMACEUTICAL INC | BMRN | Sale | Common Stock | 2.5k | $29.41 | $73.5k | | 09/01/2011 |
| 09/01/2011 | BIOMARIN PHARMACEUTICAL INC | BMRN | Exercise | Common Stock | 2.5k | $0.00 | $0 | | 09/01/2011 |
| 07/14/2011 | BIOMARIN PHARMACEUTICAL INC | BMRN | Exercise | Stock Option (right to buy) | 18.4k | $17.54 | $322.4k | | 07/14/2011 |
| 07/14/2011 | BIOMARIN PHARMACEUTICAL INC | BMRN | Sale | Common Stock | 18.4k | $30.00 | $551.3k | | 07/14/2011 |
| 05/26/2011 | BIOMARIN PHARMACEUTICAL INC | BMRN | Sale | Common Stock | 17.5k | $27.50 | $481.2k | | 05/26/2011 |
| 05/26/2011 | BIOMARIN PHARMACEUTICAL INC | BMRN | Exercise | Stock Option (right to buy) | 17.5k | $14.39 | $251.8k | | 05/26/2011 |
| 05/30/2010 | BIOMARIN PHARMACEUTICAL INC | BMRN | Grant | Common Stock | 1.5k | $11.64 | $17.5k | | 04/30/2010 |
| 05/12/2010 | BIOMARIN PHARMACEUTICAL INC | BMRN | Grant | Common Stock | 8.4k | $0.00 | $0 | | 04/30/2010 |
| 05/12/2010 | BIOMARIN PHARMACEUTICAL INC | BMRN | Grant | Stock Option (right to buy) | 63k | $21.51 | $1.4M | | 04/30/2010 |