| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Common Stock | 280.2k | $0.00 | $0 | See Footnote | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 9.4k | $20.47 | $191.9k | | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 9.4k | $31.85 | $298.6k | | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 7.8k | $35.72 | $278.6k | | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 7.8k | $38.13 | $297.4k | | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 16.3k | $45.59 | $743.1k | | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 16.3k | $56.70 | $924.2k | | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 16.3k | $36.59 | $596.4k | | 11/04/2016 |
| 11/04/2016 | GUTSHALL THOMAS L | Director | Disposition | Common Stock | 107k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | KOCMOND WARREN C JR | President & COO | Disposition | Common Stock | 25.2k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | KOCMOND WARREN C JR | President & COO | Disposition | Performance Stock Unit | 37.5k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | KOCMOND WARREN C JR | President & COO | Disposition | Restricted Stock Units | 3.3k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | KOCMOND WARREN C JR | President & COO | Disposition | Employee Stock Option (Right to Buy) | 37.5k | $38.47 | $1.4M | | 11/04/2016 |
| 11/04/2016 | KOCMOND WARREN C JR | President & COO | Disposition | Employee Stock Option (Right to Buy) | 41.2k | $45.84 | $1.9M | | 11/04/2016 |
| 11/04/2016 | KOCMOND WARREN C JR | President & COO | Disposition | Employee Stock Option (Right to Buy) | 56.2k | $56.88 | $3.2M | | 11/04/2016 |
| 11/04/2016 | KOCMOND WARREN C JR | President & COO | Disposition | Employee Stock Option (Right to Buy) | 112.5k | $29.50 | $3.3M | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Common Stock | 270.5k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Common Stock | 45k | $0.00 | $0 | See Footnote | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 9.4k | $20.47 | $191.9k | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 9.4k | $31.85 | $298.6k | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 7.8k | $35.72 | $278.6k | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 7.8k | $38.13 | $297.4k | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 16.3k | $45.59 | $743.1k | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 16.3k | $56.70 | $924.2k | | 11/04/2016 |
| 11/04/2016 | KEPNER CRISTINA | Director | Disposition | Non-Qualified Stock Option (Right to Buy) | 16.3k | $36.59 | $596.4k | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Common Stock | 14.4k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Performance Stock Unit | 25.2k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Restricted Stock Units | 2.4k | $0.00 | $0 | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Employee Stock Option (Right to Buy) | 48.8k | $20.47 | $997.9k | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Employee Stock Option (Right to Buy) | 43.5k | $31.49 | $1.4M | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Employee Stock Option (Right to Buy) | 48.8k | $35.72 | $1.7M | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Employee Stock Option (Right to Buy) | 52.5k | $38.66 | $2M | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Employee Stock Option (Right to Buy) | 41.2k | $45.84 | $1.9M | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Employee Stock Option (Right to Buy) | 56.2k | $56.88 | $3.2M | | 11/04/2016 |
| 11/04/2016 | PERSING DAVID H | EVP, Chief Med/Tech Officer | Disposition | Employee Stock Option (Right to Buy) | 50.5k | $35.94 | $1.8M | | 11/04/2016 |
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