| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/06/2023 | SCHAEFFER LEONARD D | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 06/06/2023 | Hudson Frederick M. | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 06/06/2023 | Khattar Jack A. | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 06/06/2023 | VEITINGER KLAUS R DR | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 06/06/2023 | Bonstein Sara | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 06/06/2023 | Agger Mette Kirstine | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 06/06/2023 | Baylor-Henry Minnie | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 06/06/2023 | Abraham William Tober | Director | Grant | Stock Option (Right to Buy) | 17.3k | $11.71 | $202.6k | | 06/06/2023 |
| 01/19/2023 | Nokes Rachael | See Remarks | Grant | Common Stock | 11.7k | $6.14 | $71.8k | | 02/25/2022 |
| 01/19/2023 | Nokes Rachael | See Remarks | Grant | Stock Option (right to buy) | 17.6k | $6.14 | $107.8k | | 02/25/2022 |
| 01/19/2023 | Tucker John H | President and CEO | Grant | Common Stock | 66.7k | $6.14 | $409.3k | | 01/19/2023 |
| 01/19/2023 | Tucker John H | President and CEO | Grant | Stock Option (right to buy) | 100k | $6.14 | $614k | | 01/19/2023 |
| 12/15/2022 | Nokes Rachael | See Remarks | Grant | Stock Option (right to buy) | 85.8k | $6.48 | $555.7k | | 12/15/2022 |
| 11/25/2022 | ORBIMED ADVISORS LLC | 10% Owner | Purchase | Common Stock | 762.4k | $5.25 | $4M | See Footnotes | 11/25/2022 |
| 10/10/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 456.4k | $4.09 | $1.9M | By 5AM Ventures IV, L.P. | 10/06/2022 |
| 10/10/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 87k | $4.09 | $356k | By 5AM Opportunities I, L.P. | 10/06/2022 |
| 10/10/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 19k | $4.09 | $77.8k | By 5AM Co-Investors IV, L.P. | 10/06/2022 |
| 10/07/2022 | Tucker John H | President and CEO | Payment of Exercise | Common Stock | 10.3k | $4.98 | $51.2k | | 10/07/2022 |
| 10/07/2022 | Tucker John H | President and CEO | Exercise | Restricted Stock Units | 42.2k | $0.00 | $0 | | 10/07/2022 |
| 10/07/2022 | Tucker John H | President and CEO | Grant | Stock Option (right to buy) | 42.2k | $3.25 | $137.3k | | 10/07/2022 |
| 10/06/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 30.5k | $5.02 | $152.9k | By 5AM Ventures IV, L.P. | 10/06/2022 |
| 10/06/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 1.3k | $5.02 | $6.4k | By 5AM Co-Investors IV, L.P. | 10/06/2022 |
| 10/06/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 5.8k | $5.02 | $29.2k | By 5AM Opportunities I, L.P. | 10/06/2022 |
| 09/07/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 163k | $4.75 | $774.4k | By 5AM Ventures IV, L.P. | 09/06/2022 |
| 09/07/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 6.8k | $4.75 | $32.3k | By 5AM Co-Investors IV, L.P. | 09/06/2022 |
| 09/07/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 30.2k | $4.75 | $143.3k | By 5AM Opportunities I, L.P. | 09/06/2022 |
| 09/06/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 21.7k | $5.52 | $119.8k | By 5AM Ventures IV, L.P. | 09/06/2022 |
| 09/06/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 904 | $5.52 | $5k | By 5AM Co-Investors IV, L.P. | 09/06/2022 |
| 09/06/2022 | 5AM Partners IV, LLC | 10% Owner | Sale | Common Stock | 4k | $5.52 | $22.2k | By 5AM Opportunities I, L.P. | 09/06/2022 |
| 06/14/2022 | Baylor-Henry Minnie | Director | Grant | Stock Option (Right to Buy) | 16.3k | $4.53 | $73.8k | | 06/14/2022 |
| 06/14/2022 | Abraham William Tober | Director | Grant | Stock Option (Right to Buy) | 16.3k | $4.53 | $73.8k | | 06/14/2022 |
| 06/14/2022 | Bonstein Sara | Director | Grant | Stock Option (right to buy) | 16.3k | $4.53 | $73.8k | | 06/14/2022 |
| 06/14/2022 | Khattar Jack A. | Director | Grant | Stock Option (Right to Buy) | 16.3k | $4.53 | $73.8k | | 06/14/2022 |
| 06/14/2022 | VEITINGER KLAUS R DR | Director | Grant | Stock Option (Right to Buy) | 16.3k | $4.53 | $73.8k | | 06/14/2022 |
| 06/14/2022 | SCHAEFFER LEONARD D | Director | Grant | Stock Option (Right to Buy) | 16.3k | $4.53 | $73.8k | | 06/14/2022 |
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