| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/03/2012 | MORGANROTH JOEL M D | Exec VP, Chief Scientific Off | Disposition | Option (Right to Buy) | 80.1k | $6.46 | $517.4k | | 07/03/2012 |
| 07/03/2012 | MORGANROTH JOEL M D | Exec VP, Chief Scientific Off | Disposition | Option (Right to Buy) | 43.3k | $6.05 | $261.7k | | 07/03/2012 |
| 07/03/2012 | MORGANROTH JOEL M D | Exec VP, Chief Scientific Off | Disposition | Option (Right to Buy) | 70k | $4.60 | $322k | | 07/03/2012 |
| 07/03/2012 | MORGANROTH JOEL M D | Exec VP, Chief Scientific Off | Disposition | Option (Right to Buy) | 30k | $7.41 | $222.3k | | 07/03/2012 |
| 07/03/2012 | MORGANROTH JOEL M D | Exec VP, Chief Scientific Off | Disposition | Option (Right to Buy) | 90k | $6.29 | $566.1k | | 07/03/2012 |
| 07/03/2012 | MORGANROTH JOEL M D | Exec VP, Chief Scientific Off | Disposition | Common Stock, $.01 par value | 19.1k | $0.00 | $0 | | 07/03/2012 |
| 07/03/2012 | MORGANROTH JOEL M D | Exec VP, Chief Scientific Off | Disposition | Common Stock, $.01 par value | 1.3M | $8.00 | $10.1M | | 07/03/2012 |
| 07/03/2012 | Scheppmann Stephen Mark | Director | Disposition | Option (Right to Buy) | 22k | $4.60 | $101.2k | | 07/03/2012 |
| 07/03/2012 | Scheppmann Stephen Mark | Director | Disposition | Option (Right to Buy) | 9.2k | $7.37 | $67.9k | | 07/03/2012 |
| 07/03/2012 | Scheppmann Stephen Mark | Director | Disposition | Option (Right to Buy) | 10.9k | $6.21 | $67.5k | | 07/03/2012 |
| 07/03/2012 | Scheppmann Stephen Mark | Director | Disposition | Common Stock, $.01 par value | 9.6k | $8.00 | $77.1k | | 07/03/2012 |
| 07/03/2012 | HITCHNER ELAM M III | Director | Disposition | Common Stock, $.01 par value | 17.1k | $8.00 | $137.1k | | 07/03/2012 |
| 07/03/2012 | HITCHNER ELAM M III | Director | Disposition | Option (Right to Buy) | 10.9k | $6.21 | $67.5k | | 07/03/2012 |
| 07/03/2012 | HITCHNER ELAM M III | Director | Disposition | Option (Right to Buy) | 9.2k | $7.37 | $67.9k | | 07/03/2012 |
| 07/03/2012 | HITCHNER ELAM M III | Director | Disposition | Option (Right to Buy) | 22k | $4.60 | $101.2k | | 07/03/2012 |
| 07/03/2012 | PHILLIPS STEPHENS S | Director | Disposition | Common Stock, $.01 par value | 193.5k | $8.00 | $1.5M | | 07/03/2012 |
| 07/03/2012 | PHILLIPS STEPHENS S | Director | Disposition | Option (Right to Buy) | 10.9k | $6.21 | $67.5k | | 07/03/2012 |
| 07/03/2012 | PHILLIPS STEPHENS S | Director | Disposition | Option (Right to Buy) | 9.2k | $7.37 | $67.9k | | 07/03/2012 |
| 07/03/2012 | PHILLIPS STEPHENS S | Director | Disposition | Option (Right to Buy) | 22k | $4.60 | $101.2k | | 07/03/2012 |
| 07/03/2012 | PHILLIPS STEPHENS S | Director | Disposition | Option (Right to Buy) | 45k | $6.29 | $283k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Common Stock, $.01 par value | 15.5k | $0.00 | $0 | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Common Stock, $.01 par value | 10k | $8.00 | $80k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Common Stock, $.01 par value | 24.7k | $8.00 | $197.9k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Option (Right to Buy) | 31.6k | $6.46 | $203.8k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Option (Right to Buy) | 28.5k | $6.05 | $172.7k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Option (Right to Buy) | 50k | $4.60 | $230k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Option (Right to Buy) | 20k | $7.41 | $148.2k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Option (Right to Buy) | 43.7k | $6.29 | $274.8k | | 07/03/2012 |
| 07/03/2012 | DEVINE THOMAS P | Exec VP, Chief Information Off | Disposition | Option (Right to Buy) | 17.4k | $4.21 | $73.1k | | 07/03/2012 |
| 07/03/2012 | FURLONG AMY | Exec VP, Chief Operations Off | Disposition | Common Stock, $.01 par value | 16.2k | $0.00 | $0 | | 07/03/2012 |
| 07/03/2012 | FURLONG AMY | Exec VP, Chief Operations Off | Disposition | Common Stock, $.01 par value | 7.4k | $8.00 | $59k | | 07/03/2012 |
| 07/03/2012 | FURLONG AMY | Exec VP, Chief Operations Off | Disposition | Common Stock, $.01 par value | 19k | $8.00 | $152.2k | | 07/03/2012 |
| 07/03/2012 | FURLONG AMY | Exec VP, Chief Operations Off | Disposition | Option (Right to Buy) | 33k | $6.46 | $213.2k | | 07/03/2012 |
| 07/03/2012 | FURLONG AMY | Exec VP, Chief Operations Off | Disposition | Option (Right to Buy) | 30.1k | $6.05 | $182.1k | | 07/03/2012 |
| 07/03/2012 | FURLONG AMY | Exec VP, Chief Operations Off | Disposition | Option (Right to Buy) | 50k | $4.60 | $230k | | 07/03/2012 |
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