| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/24/2023 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Option to Purchase Common Stock | 12.5k | $9.17 | $115.1k | | 05/24/2023 |
| 05/24/2023 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Common Stock | 8.1k | $0.00 | $0 | | 05/24/2023 |
| 03/31/2023 | Prime Medicine, Inc. | | Grant | Stock Option (right to buy) | 497.7k | $12.30 | $6.1M | | 03/31/2023 |
| 05/27/2021 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Common Stock | 7k | $0.00 | $0 | | 05/27/2021 |
| 05/27/2021 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Option to Purchase Common Stock | 12.1k | $17.08 | $206.5k | | 05/27/2021 |
| 05/28/2020 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Common Stock | 1.6k | $0.00 | $0 | | 05/28/2020 |
| 05/28/2020 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Option to Purchase Common Stock | 3k | $72.74 | $215.7k | | 05/28/2020 |
| 03/09/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Employee Stock Option (Right to Buy) | 3.4k | $6.14 | $20.9k | | 03/09/2020 |
| 02/10/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Employee Stock Option (Right to Buy) | 6.8k | $6.14 | $41.9k | | 02/10/2020 |
| 01/08/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Employee Stock Option (Right to Buy) | 33.1k | $4.59 | $151.8k | | 01/08/2020 |
| 07/16/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Employee Stock Option (Right to Buy) | 7.5k | $4.59 | $34.4k | | 07/16/2019 |
| 06/20/2019 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Option to Purchase Common Stock | 2.2k | $82.25 | $178.8k | | 06/20/2019 |
| 06/20/2019 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Common Stock | 1.6k | $0.00 | $0 | | 06/20/2019 |
| 03/18/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 2.3k | $30.27 | $70.5k | | 03/15/2019 |
| 03/15/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 8k | $30.04 | $239.1k | | 03/15/2019 |
| 03/14/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 1.5k | $30.05 | $45.3k | | 03/13/2019 |
| 03/13/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 7.8k | $30.06 | $233.9k | | 03/13/2019 |
| 02/27/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 1.8k | $30.01 | $54.4k | | 02/26/2019 |
| 02/26/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 635 | $30.13 | $19.1k | | 02/26/2019 |
| 02/19/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 918 | $30.05 | $27.6k | | 02/15/2019 |
| 02/15/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 12k | $30.02 | $360.3k | | 02/15/2019 |
| 02/13/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 3.9k | $30.00 | $118k | | 02/13/2019 |
| 02/13/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Grant | Employee Stock Option (Right to Buy) | 225k | $29.78 | $6.7M | | 02/13/2019 |
| 01/23/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 105 | $30.21 | $3.2k | | 01/22/2019 |
| 01/22/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 15.7k | $30.05 | $471k | | 01/22/2019 |
| 01/18/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 10.1k | $30.01 | $303.6k | | 01/18/2019 |
| 01/16/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 662 | $30.00 | $19.9k | | 01/16/2019 |
| 12/03/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 563 | $30.00 | $16.9k | | 12/03/2018 |
| 11/02/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 16.5k | $30.08 | $496.3k | | 11/02/2018 |
| 06/20/2018 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Option to Purchase Common Stock | 2.7k | $85.12 | $233.9k | | 06/20/2018 |
| 06/20/2018 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Grant | Common Stock | 1.8k | $0.00 | $0 | | 06/20/2018 |
| 05/09/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Employee Stock Option (Right to Buy) | 3k | $4.59 | $13.8k | | 05/09/2018 |
| 04/09/2018 | INTERCEPT PHARMACEUTICALS, INC. | ICPT | Purchase | Common Stock | 1.2k | $64.00 | $74.9k | | 04/09/2018 |
| 02/14/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Grant | Employee Stock Option (Right to Buy) | 175k | $25.79 | $4.5M | | 02/14/2018 |
| 10/10/2017 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Conversion | Common Stock | 27.3k | $0.00 | $0 | | 10/10/2017 |
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