| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Common Stock | 150k | $0.00 | $0 | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Disposition | Stock Options (Right to buy) | 190.9k | $15.08 | $2.9M | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Disposition | Stock Options (Right to buy) | 42.6k | $15.00 | $638.8k | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Disposition | Stock Options (Right to buy) | 41k | $2.32 | $95k | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Disposition | Stock Options (Right to buy) | 93.8k | $2.32 | $217.5k | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Options (Right to buy) | 42.6k | $0.71 | $30.2k | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Options (Right to buy) | 190.9k | $0.71 | $135.5k | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Options (Right to buy) | 41k | $0.71 | $29.1k | | 08/06/2019 |
| 08/06/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Options (Right to buy) | 93.8k | $0.71 | $66.6k | | 08/06/2019 |
| 07/02/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Payment of Exercise | Common Stock | 17.1k | $0.76 | $13k | | 07/02/2019 |
| 02/22/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Purchase | Common Stock | 40k | $2.50 | $100k | | 02/22/2019 |
| 01/01/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Common Stock | 187.5k | $0.00 | $0 | | 01/01/2019 |
| 01/01/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Options (Right to buy) | 41k | $2.32 | $95k | | 01/01/2019 |
| 01/01/2019 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Options (Right to buy) | 93.8k | $2.32 | $217.5k | | 01/01/2019 |
| 06/01/2018 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Options (Right to buy) | 190.9k | $15.08 | $2.9M | | 06/01/2018 |
| 05/17/2018 | Sienna Biopharmaceuticals, Inc. | SNNA | Other (acquisition) | Common Stock | 47.6k | $0.00 | $0 | | 05/17/2018 |
| 08/01/2017 | Sienna Biopharmaceuticals, Inc. | SNNA | Conversion | Common Stock | 14.1k | $0.00 | $0 | See Footnote | 08/01/2017 |
| 08/01/2017 | Sienna Biopharmaceuticals, Inc. | SNNA | Conversion | Common Stock | 14.1k | $0.00 | $0 | See Footnote | 08/01/2017 |
| 08/01/2017 | Sienna Biopharmaceuticals, Inc. | SNNA | Conversion | Common Stock | 112.6k | $0.00 | $0 | See Footnote | 08/01/2017 |
| 08/01/2017 | Sienna Biopharmaceuticals, Inc. | SNNA | Conversion | Series A-3 Preferred Stock | 14.1k | $0.00 | $0 | See Footnote | 08/01/2017 |
| 08/01/2017 | Sienna Biopharmaceuticals, Inc. | SNNA | Conversion | Series A-3 Preferred Stock | 14.1k | $0.00 | $0 | See Footnote | 08/01/2017 |
| 08/01/2017 | Sienna Biopharmaceuticals, Inc. | SNNA | Conversion | Series A-3 Preferred Stock | 112.6k | $0.00 | $0 | See Footnote | 08/01/2017 |
| 07/26/2017 | Sienna Biopharmaceuticals, Inc. | SNNA | Grant | Stock Option (Right to Buy) | 42.6k | $15.00 | $638.8k | | 07/26/2017 |