| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/09/2022 | Editas Medicine, Inc. | EDIT | Grant | Stock Option (right to buy) | 25k | $12.31 | $307.8k | | 06/09/2022 |
| 05/26/2022 | C4 Therapeutics, Inc. | | Payment of Exercise | Common Stock | 3.7k | $7.01 | $25.8k | | 05/26/2022 |
| 05/25/2022 | C4 Therapeutics, Inc. | | Exercise | Performance Restricted Stock Units | 12.5k | $0.00 | $0 | | 05/25/2022 |
| 04/12/2022 | C4 Therapeutics, Inc. | | Purchase | Common Stock | 10k | $8.40 | $84k | | 04/12/2022 |
| 02/23/2022 | C4 Therapeutics, Inc. | | Grant | Performance Restricted Stock Units | 87.5k | $0.00 | $0 | | 02/23/2022 |
| 06/03/2021 | Editas Medicine, Inc. | EDIT | Grant | Stock Option (right to buy) | 11.5k | $33.36 | $384.9k | | 06/03/2021 |
| 10/01/2020 | C4 Therapeutics, Inc. | | Grant | Stock Option (Right to Buy) | 1.7M | $19.00 | $32.1M | | 10/01/2020 |
| 06/10/2020 | Editas Medicine, Inc. | EDIT | Grant | Stock Option (right to buy) | 11.5k | $27.49 | $317.2k | | 06/10/2020 |
| 04/22/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 1.9k | $45.91 | $88.5k | | 04/22/2020 |
| 04/22/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 5.9k | $0.00 | $0 | | 04/22/2020 |
| 04/14/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 1.6k | $40.64 | $65k | | 04/13/2020 |
| 04/13/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Performance share units | 5.4k | $0.00 | $0 | | 04/13/2020 |
| 02/24/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 1.1k | $48.66 | $51.4k | | 02/22/2020 |
| 02/22/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 3.3k | $0.00 | $0 | | 02/22/2020 |
| 02/18/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 886 | $52.01 | $46.1k | | 02/14/2020 |
| 02/16/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 2.8k | $0.00 | $0 | | 02/14/2020 |
| 02/14/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 12k | $0.00 | $0 | | 02/14/2020 |
| 02/14/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock option (right to buy) | 45k | $51.51 | $2.3M | | 02/14/2020 |
| 06/12/2019 | Editas Medicine, Inc. | EDIT | Grant | Stock Option (right to buy) | 11.5k | $21.74 | $250.8k | | 06/12/2019 |
| 04/22/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 17.7k | $0.00 | $0 | | 04/22/2019 |
| 02/22/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 10k | $0.00 | $0 | | 02/22/2019 |
| 02/22/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock option (right to buy) | 40k | $58.86 | $2.4M | | 02/22/2019 |
| 02/19/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 821 | $58.03 | $47.6k | | 02/16/2019 |
| 02/16/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 2.8k | $0.00 | $0 | | 02/16/2019 |
| 01/22/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 4.6k | $52.82 | $240.6k | | 01/20/2019 |
| 01/20/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Performance share unit | 15k | $0.00 | $0 | | 01/20/2019 |
| 07/20/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Performance share units | 15k | $0.00 | $0 | | 07/20/2018 |
| 06/15/2018 | Editas Medicine, Inc. | EDIT | Grant | Stock Option (right to buy) | 11.5k | $37.50 | $432.7k | | 06/15/2018 |
| 02/16/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock option (right to buy) | 33k | $77.70 | $2.6M | | 02/16/2018 |
| 02/16/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 8.2k | $0.00 | $0 | | 02/16/2018 |
| 05/30/2017 | Editas Medicine, Inc. | EDIT | Grant | Stock Option (right to buy) | 23.1k | $13.75 | $317.3k | | 05/30/2017 |
| 02/21/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock option (right to buy) | 47.6k | $50.40 | $2.4M | | 02/21/2017 |