| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/31/2023 | Syros Pharmaceuticals, Inc. | SYRS | Sale | Common Stock | 7.3k | $3.95 | $29k | | 07/31/2023 |
| 04/03/2023 | Syros Pharmaceuticals, Inc. | SYRS | Payment of Exercise | Common Stock | 623 | $2.58 | $1.6k | | 03/31/2023 |
| 03/31/2023 | Syros Pharmaceuticals, Inc. | SYRS | Exercise | Restricted Stock Units | 2k | $0.00 | $0 | | 03/31/2023 |
| 10/06/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Restricted Stock Units | 37.8k | $0.00 | $0 | | 10/06/2022 |
| 10/06/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 49.8k | $6.73 | $334.8k | | 10/06/2022 |
| 04/01/2022 | Syros Pharmaceuticals, Inc. | SYRS | Payment of Exercise | Common Stock | 27.3k | $1.12 | $30.6k | | 04/01/2022 |
| 02/15/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Restricted Stock Units | 80k | $0.00 | $0 | | 02/15/2022 |
| 02/15/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 125k | $1.59 | $198.8k | | 02/15/2022 |
| 02/15/2022 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Restricted Stock Units | 200k | $0.00 | $0 | | 02/15/2022 |
| 02/17/2021 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 119k | $11.41 | $1.4M | | 02/17/2021 |
| 02/13/2020 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 94k | $7.54 | $708.8k | | 02/13/2020 |
| 02/12/2019 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 75k | $6.71 | $503.2k | | 02/12/2019 |
| 02/12/2019 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Common Stock | 87k | $0.00 | $0 | | 02/12/2019 |
| 02/16/2018 | Syros Pharmaceuticals, Inc. | SYRS | Grant | Stock Option (right to buy) | 75k | $10.09 | $756.8k | | 02/16/2018 |