| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/17/2023 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 922 | $13.86 | $12.8k | | 08/15/2023 |
| 08/15/2023 | Day One Biopharmaceuticals, Inc. | | Exercise | Restricted Stock Units | 2.2k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Day One Biopharmaceuticals, Inc. | | Exercise | Restricted Stock Units | 1.4k | $0.00 | $0 | | 08/15/2023 |
| 05/16/2023 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 955 | $13.12 | $12.5k | | 05/15/2023 |
| 05/15/2023 | Day One Biopharmaceuticals, Inc. | | Exercise | Restricted Stock Units | 1.4k | $0.00 | $0 | | 05/15/2023 |
| 05/15/2023 | Day One Biopharmaceuticals, Inc. | | Exercise | Restricted Stock Units | 2.2k | $0.00 | $0 | | 05/15/2023 |
| 02/17/2023 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 9.4k | $20.03 | $187.8k | | 02/17/2023 |
| 01/20/2023 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 10k | $22.75 | $227.5k | | 01/20/2023 |
| 01/17/2023 | Day One Biopharmaceuticals, Inc. | | Grant | Restricted Stock Units | 36k | $0.00 | $0 | | 01/17/2023 |
| 01/17/2023 | Day One Biopharmaceuticals, Inc. | | Grant | Stock Option (right to buy Common Stock) | 116k | $20.87 | $2.4M | | 01/17/2023 |
| 11/21/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 9.7k | $20.74 | $201.2k | | 11/21/2022 |
| 11/21/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 300 | $21.39 | $6.4k | | 11/21/2022 |
| 11/16/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 430 | $21.46 | $9.2k | | 11/15/2022 |
| 11/15/2022 | Day One Biopharmaceuticals, Inc. | | Exercise | Restricted Stock Units | 1.4k | $0.00 | $0 | | 11/15/2022 |
| 11/01/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 10k | $20.03 | $200.3k | | 11/01/2022 |
| 10/03/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 10k | $20.05 | $200.5k | | 10/03/2022 |
| 09/01/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 8.6k | $23.16 | $199.3k | | 09/01/2022 |
| 09/01/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 1.4k | $23.80 | $33.2k | | 09/01/2022 |
| 08/16/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 1.1k | $24.31 | $26.5k | | 08/15/2022 |
| 08/15/2022 | Day One Biopharmaceuticals, Inc. | | Exercise | Restricted Stock Units | 4.1k | $0.00 | $0 | | 08/15/2022 |
| 08/04/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 10k | $20.05 | $200.5k | | 08/04/2022 |
| 07/18/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 2.5k | $20.00 | $50k | | 07/18/2022 |
| 07/08/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 1.4k | $20.00 | $28.3k | | 07/08/2022 |
| 07/05/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 800 | $20.00 | $16k | | 07/01/2022 |
| 07/01/2022 | Day One Biopharmaceuticals, Inc. | | Sale | Common Stock | 1.5k | $20.00 | $29.6k | | 07/01/2022 |
| 01/18/2022 | Day One Biopharmaceuticals, Inc. | | Grant | Stock Option (right to buy Common Stock) | 151k | $14.26 | $2.2M | | 01/18/2022 |
| 01/18/2022 | Day One Biopharmaceuticals, Inc. | | Grant | Restricted Stock Units | 22k | $0.00 | $0 | | 01/18/2022 |
| 02/14/2020 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Employee Stock Option (right to buy) | 126k | $8.15 | $1M | | 02/14/2020 |
| 02/28/2019 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Employee Stock Option (right to buy) | 87.6k | $8.36 | $732.3k | | 02/28/2019 |
| 02/20/2018 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Employee Stock Option (right to buy) | 92.1k | $6.31 | $581.2k | | 02/20/2018 |
| 12/05/2017 | Aeglea BioTherapeutics, Inc. | AGLE | Purchase | Common Stock | 10.2k | $4.76 | $48.7k | | 12/01/2017 |
| 12/04/2017 | Aeglea BioTherapeutics, Inc. | AGLE | Purchase | Common Stock | 3.3k | $4.97 | $16.2k | | 12/01/2017 |
| 12/01/2017 | Aeglea BioTherapeutics, Inc. | AGLE | Purchase | Common Stock | 6.5k | $4.59 | $29.9k | | 12/01/2017 |
| 08/15/2017 | Aeglea BioTherapeutics, Inc. | AGLE | Purchase | Common Stock | 2k | $2.52 | $4.9k | | 12/01/2017 |
| 03/20/2017 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Employee Stock Option (right to buy) | 90k | $8.03 | $722.7k | | 03/20/2017 |
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