| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/24/2019 | FROST PHILLIP MD ET AL | 10% Owner | Conversion | Series D Convertible Preferred Stock | 1.3k | $0.00 | $0 | Frost Gamma Investments Trust | 01/24/2019 |
| 01/24/2019 | FROST PHILLIP MD ET AL | 10% Owner | Conversion | Common Stock, $0.01 par value per share | 6.3M | $0.00 | $0 | Frost Gamma Investments Trust | 01/24/2019 |
| 12/21/2018 | HSIAO JANE PH D | Interim CEO | Purchase | Common Stock, $0.01 par value per share | 20.9M | $0.07 | $1.5M | See Footnote | 12/21/2018 |
| 12/21/2018 | HSIAO JANE PH D | Interim CEO | Purchase | Common Stock, $0.01 par value per share | 4.9M | $0.07 | $344.6k | | 12/21/2018 |
| 12/21/2018 | HSIAO JANE PH D | Interim CEO | Purchase | Common Stock, $0.01 par value per share | 1.4M | $0.07 | $100k | | 12/21/2018 |
| 12/21/2018 | FROST PHILLIP MD ET AL | 10% Owner | Purchase | Common Stock, $0.01 par value per share | 26.2M | $0.07 | $1.8M | Frost Gamma Investments Trust | 12/21/2018 |
| 12/21/2018 | FROST PHILLIP MD ET AL | 10% Owner | Purchase | Common Stock, $0.01 par value per share | 7.1M | $0.07 | $500k | Frost Gamma Investments Trust | 12/21/2018 |
| 08/15/2014 | Sackner Marvin Arthur | Director | Sale | Common Stock, $0.01 par value | 1.7M | $0.11 | $189.9k | | 08/15/2014 |
| 08/15/2014 | Sackner Marvin Arthur | Director | Sale | Common Stock, $0.01 par value | 6.6k | $0.11 | $729.2 | Held by Spouse | 08/15/2014 |
| 08/15/2014 | Sackner Marvin Arthur | Director | Sale | Series C Convertible Stock | 35.8k | $0.00 | $0 | | 08/15/2014 |
| 08/15/2014 | Sackner Marvin Arthur | Director | Sale | Series C Convertible Stock | 1k | $0.00 | $0 | Held by Spouse | 08/15/2014 |
| 08/15/2014 | Sackner Marvin Arthur | Director | Sale | Series D Convertible Stock | 50 | $550.00 | $27.5k | | 08/15/2014 |
| 08/15/2014 | Martin James Joseph | CFO | Purchase | Common Stock, $0.01 par value | 25k | $0.11 | $2.8k | | 08/15/2014 |
| 08/09/2013 | Sackner Marvin Arthur | Director | Sale | Common Stock, $0.01 par value | 37k | $0.22 | $8.1k | | 08/07/2013 |
| 08/07/2013 | Sackner Marvin Arthur | Director | Sale | Common Stock, $0.01 par value | 13k | $0.23 | $3k | | 08/07/2013 |
| 04/08/2013 | HSIAO JANE PH D | Interim CEO | Purchase | Common Stock, $0.01 par value | 2M | $0.05 | $100k | | 04/08/2013 |
| 04/08/2013 | FROST PHILLIP MD ET AL | 10% Owner | Purchase | Common Stock, $0.01 par value | 2M | $0.05 | $100k | Frost Gamma Investments Trust | 04/08/2013 |
| 04/08/2013 | HSIAO JANE PH D | Interim CEO | Purchase | Common Stock, $0.01 par value | 20M | $0.05 | $1000k | | 04/08/2013 |
| 02/28/2012 | Rubin Steven D | Director | Purchase | Common Stock, $0.01 par value | 100k | $0.05 | $5k | | 02/28/2012 |
| 02/28/2012 | FROST PHILLIP MD ET AL | 10% Owner | Purchase | Common Stock, $0.01 par value | 1.5M | $0.05 | $75k | Frost Gamma Investments Trust | 02/28/2012 |
| 03/08/2010 | Rubin Steven D | Director | Grant | Stock Option (Right to Buy) | 15k | $0.43 | $6.4k | | 03/08/2010 |
| 03/08/2010 | UPPALURI SUBBARAO V | Director | Grant | Stock Option (Right to Buy) | 15k | $0.43 | $6.4k | | 03/08/2010 |
| 03/08/2010 | Jackson Adam S | CFO | Grant | Stock Option (Right to Buy) | 25k | $0.43 | $10.8k | | 03/08/2010 |
| 03/08/2010 | Mrha Steven | COO | Grant | Stock Option (Right to Buy) | 75k | $0.43 | $32.2k | | 03/08/2010 |
| 03/08/2010 | Robinson Morton J | Director | Grant | Stock Option (Right to Buy) | 10k | $0.43 | $4.3k | | 03/08/2010 |
| 02/01/2010 | Sackner Marvin Arthur | Director | Gift | Common Stock | 175k | $0.00 | $0 | | 02/01/2010 |