| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/29/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Purchase | Common Stock | 10k | $2.16 | $21.6k | | 06/29/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 91.4k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 33.3k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 84.6k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 51k | $2.17 | $110.6k | | 02/28/2023 |
| 08/08/2022 | Verve Therapeutics, Inc. | | Grant | Stock Option (right to buy) | 31k | $27.17 | $842.3k | | 08/08/2022 |
| 06/21/2022 | Blueprint Medicines Corp | BPMC | Grant | Common Stock | 2.6k | $0.00 | $0 | | 06/21/2022 |
| 06/21/2022 | Blueprint Medicines Corp | BPMC | Grant | Stock Option (Right to Buy) | 5.3k | $50.64 | $268.4k | | 06/21/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 48.1k | $2.85 | $137k | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 79.4k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 84.6k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 33.3k | $0.00 | $0 | | 02/28/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 274.1k | $0.00 | $0 | | 02/10/2022 |
| 02/10/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 822.3k | $3.20 | $2.6M | | 02/10/2022 |
| 06/02/2021 | Blueprint Medicines Corp | BPMC | Grant | Common Stock | 2.2k | $0.00 | $0 | | 06/02/2021 |
| 06/02/2021 | Blueprint Medicines Corp | BPMC | Grant | Stock Option (Right to Buy) | 4.5k | $87.13 | $392.1k | | 06/02/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 55k | $7.19 | $395.7k | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 5.4k | $0.00 | $0 | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 23.5k | $0.00 | $0 | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 79.4k | $0.00 | $0 | | 02/28/2021 |
| 02/28/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 84.6k | $0.00 | $0 | | 02/28/2021 |
| 02/11/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 100k | $0.00 | $0 | | 02/11/2021 |
| 02/11/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 300k | $8.38 | $2.5M | | 02/11/2021 |
| 06/24/2020 | Blueprint Medicines Corp | BPMC | Grant | Common Stock | 2.2k | $0.00 | $0 | | 06/24/2020 |
| 06/24/2020 | Blueprint Medicines Corp | BPMC | Grant | Stock Option (Right to Buy) | 4.5k | $76.24 | $343.1k | | 06/24/2020 |
| 06/19/2020 | Blueprint Medicines Corp | BPMC | Exercise | Restricted Stock Units | 1.3k | $0.00 | $0 | | 06/19/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 8.4k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Payment of Exercise | Common Stock | 45.3k | $2.77 | $125.5k | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 23.5k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 79.4k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Exercise | Restricted Stock Units | 5.4k | $0.00 | $0 | | 02/28/2020 |
| 02/06/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Restricted Stock Units | 253.9k | $0.00 | $0 | | 02/06/2020 |
| 02/06/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | Grant | Stock Option (Right to Buy) | 761.7k | $3.31 | $2.5M | | 02/06/2020 |
| 09/18/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | Purchase | Common Stock | 50k | $3.10 | $155k | | 09/18/2019 |
| 09/17/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | Purchase | Common Stock | 277 | $3.13 | $866.9 | | 09/17/2019 |
|