| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/01/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 3.4k | $194.78 | $662.1k | | 08/01/2023 |
| 08/01/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 6.3k | $195.61 | $1.2M | | 08/01/2023 |
| 08/01/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 3.1k | $196.59 | $611.4k | | 08/01/2023 |
| 08/01/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 400 | $197.66 | $79.1k | | 08/01/2023 |
| 08/01/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 600 | $198.41 | $119k | | 08/01/2023 |
| 08/01/2023 | Karuna Therapeutics, Inc. | KRTX | Exercise | Option (right to buy) | 13.8k | $7.27 | $100.4k | | 08/01/2023 |
| 07/03/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 234 | $214.61 | $50.2k | | 07/03/2023 |
| 07/03/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 8k | $215.91 | $1.7M | | 07/03/2023 |
| 07/03/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 3.2k | $216.78 | $693.9k | | 07/03/2023 |
| 07/03/2023 | Karuna Therapeutics, Inc. | KRTX | Sale | Common Stock | 2.4k | $217.82 | $524.7k | | 07/03/2023 |
| 07/03/2023 | Karuna Therapeutics, Inc. | KRTX | Exercise | Option (right to buy) | 13.8k | $7.27 | $100.4k | | 07/03/2023 |
| 06/15/2023 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 10k | $56.10 | $561k | | 06/15/2023 |
| 06/08/2023 | Generation Bio Co. | GBIO | Grant | Stock Option (right to buy) | 25k | $4.83 | $120.8k | | 06/08/2023 |
| 02/03/2023 | Sage Therapeutics, Inc. | SAGE | Grant | Common Stock | 5.1k | $0.00 | $0 | | 02/03/2023 |
| 02/03/2023 | Sage Therapeutics, Inc. | SAGE | Payment of Exercise | Common Stock | 1.4k | $44.16 | $63k | | 02/03/2023 |
| 01/03/2023 | Sage Therapeutics, Inc. | SAGE | Exercise | Stock Option (Right to Buy) | 2.5k | $28.63 | $71.6k | | 01/03/2023 |
| 06/15/2022 | Karuna Therapeutics, Inc. | KRTX | Grant | Option (right to buy) | 5k | $102.96 | $514.8k | | 06/15/2022 |
| 06/09/2022 | Generation Bio Co. | GBIO | Grant | Stock Option (right to buy) | 19.2k | $6.19 | $118.8k | | 06/09/2022 |
| 04/27/2022 | Sage Therapeutics, Inc. | SAGE | Exercise | Stock Option (Right to Buy) | 30.9k | $0.45 | $13.9k | | 04/27/2022 |
| 02/17/2022 | Sage Therapeutics, Inc. | SAGE | Exercise | Stock Option (Right to Buy) | 4k | $0.45 | $1.8k | | 02/17/2022 |
| 02/11/2022 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 15.2k | $43.04 | $654.2k | | 02/11/2022 |
| 10/19/2021 | Sage Therapeutics, Inc. | SAGE | Grant | Common Stock | 10k | $0.00 | $0 | | 10/19/2021 |
| 10/19/2021 | Sage Therapeutics, Inc. | SAGE | Payment of Exercise | Common Stock | 4.4k | $40.29 | $176.2k | | 10/19/2021 |
| 06/16/2021 | Sage Therapeutics, Inc. | SAGE | Exercise | Stock Option (Right to Buy) | 12k | $0.45 | $5.4k | | 06/15/2021 |
| 06/16/2021 | Karuna Therapeutics, Inc. | KRTX | Grant | Option (right to buy) | 8.5k | $128.01 | $1.1M | | 06/16/2021 |
| 06/15/2021 | Sage Therapeutics, Inc. | SAGE | Grant | Common Stock | 10k | $0.00 | $0 | | 06/15/2021 |
| 06/15/2021 | Sage Therapeutics, Inc. | SAGE | Payment of Exercise | Common Stock | 3.1k | $58.80 | $181.9k | | 06/15/2021 |
| 06/09/2021 | Generation Bio Co. | GBIO | Grant | Stock Option (right to buy) | 15k | $26.59 | $398.8k | | 06/09/2021 |
| 02/10/2021 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 34k | $82.27 | $2.8M | | 02/10/2021 |
| 01/27/2021 | Sage Therapeutics, Inc. | SAGE | Exercise | Stock Option (Right to Buy) | 1.8k | $0.45 | $810 | | 01/27/2021 |
| 06/11/2020 | Generation Bio Co. | GBIO | Grant | Stock Option (right to buy) | 52k | $19.00 | $988k | | 06/11/2020 |
| 06/04/2020 | Karuna Therapeutics, Inc. | KRTX | Grant | Option (right to buy) | 12.5k | $97.59 | $1.2M | | 06/04/2020 |
| 04/28/2020 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 15.4k | $39.87 | $613.4k | | 04/28/2020 |
| 02/12/2020 | Sage Therapeutics, Inc. | SAGE | Grant | Stock Option (Right to Buy) | 50k | $68.87 | $3.4M | | 02/12/2020 |
| 12/09/2019 | Sage Therapeutics, Inc. | SAGE | Purchase | Common Stock | 7.5k | $64.20 | $481.5k | | 12/09/2019 |
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