| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 10/02/2023 | Febbo Phillip G. | Chief Scientific & Med Officer | Grant | Common Stock | 53.2k | $0.00 | $0 | | 10/02/2023 |
| 10/02/2023 | Febbo Phillip G. | Chief Scientific & Med Officer | Grant | Stock Option (right to buy) | 85.9k | $21.96 | $1.9M | | 10/02/2023 |
| 07/18/2023 | JONES EVAN/ FA | Director | Sale | Common Stock | 2.3k | $30.16 | $70.1k | | 07/17/2023 |
| 07/18/2023 | JONES EVAN/ FA | Director | Sale | Common Stock | 7.4k | $30.19 | $224.6k | by jVen Capital, LLC | 07/17/2023 |
| 07/18/2023 | BISHOP JOHN L | Director | Sale | Common Stock | 10k | $30.50 | $305k | | 07/17/2023 |
| 07/18/2023 | BISHOP JOHN L | Director | Exercise | Stock Option (right to buy) | 10k | $6.37 | $63.7k | | 07/17/2023 |
| 07/17/2023 | BISHOP JOHN L | Director | Exercise | Stock Option (right to buy) | 10k | $6.37 | $63.7k | | 07/17/2023 |
| 07/17/2023 | JONES EVAN/ FA | Director | Sale | Common Stock | 19.1k | $30.07 | $574.1k | | 07/17/2023 |
| 07/17/2023 | JONES EVAN/ FA | Director | Sale | Common Stock | 23.9k | $30.07 | $720.1k | by jVen Capital, LLC | 07/17/2023 |
| 07/17/2023 | BISHOP JOHN L | Director | Sale | Common Stock | 10k | $30.00 | $300k | | 07/17/2023 |
| 06/02/2023 | Stapley Marc | CEO | Payment of Exercise | Common Stock | 3.2k | $26.72 | $85.6k | | 06/02/2023 |
| 06/02/2023 | Wygant Jonathan | VP, Chief Accounting Officer | Payment of Exercise | Common Stock | 260 | $26.72 | $6.9k | | 06/02/2023 |
| 06/02/2023 | Anderson Bonnie H | Director | Payment of Exercise | Common Stock | 1.3k | $26.72 | $34.8k | | 06/02/2023 |
| 06/02/2023 | Chambers Rebecca | CFO | Payment of Exercise | Common Stock | 1.2k | $26.72 | $31.6k | | 06/02/2023 |
| 06/02/2023 | McGuire Annie | SVP, General Counsel | Payment of Exercise | Common Stock | 494 | $26.72 | $13.2k | | 06/02/2023 |
| 05/30/2023 | Bhanji Muna | Director | Sale | Common Stock | 1.5k | $25.91 | $39.9k | | 05/30/2023 |
| 03/16/2023 | EASTHAM KARIN | Director | Sale | Common Stock | 18.8k | $22.78 | $427k | | 03/16/2023 |
| 03/16/2023 | EASTHAM KARIN | Director | Exercise | Stock Option (right to buy) | 18.8k | $12.12 | $227.2k | | 03/16/2023 |
| 03/15/2023 | Anderson Bonnie H | Director | Sale | Common Stock | 34k | $22.76 | $773.9k | | 03/15/2023 |
| 03/15/2023 | Anderson Bonnie H | Director | Exercise | Stock Option (right to buy) | 34k | $5.61 | $190.7k | | 03/15/2023 |
| 03/06/2023 | Wygant Jonathan | VP, Chief Accounting Officer | Grant | Common Stock | 8.9k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | Wygant Jonathan | VP, Chief Accounting Officer | Grant | Stock Option (right to buy) | 14.2k | $23.73 | $337.3k | | 03/06/2023 |
| 03/06/2023 | Stapley Marc | CEO | Grant | Common Stock | 78k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | Stapley Marc | CEO | Grant | Stock Option (right to buy) | 128.9k | $23.73 | $3.1M | | 03/06/2023 |
| 03/06/2023 | McGuire Annie | SVP, General Counsel | Grant | Common Stock | 23.4k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | McGuire Annie | SVP, General Counsel | Grant | Stock Option (right to buy) | 38.7k | $23.73 | $917.4k | | 03/06/2023 |
| 03/06/2023 | Chambers Rebecca | CFO | Grant | Common Stock | 26k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | Chambers Rebecca | CFO | Grant | Stock Option (right to buy) | 43k | $23.73 | $1M | | 03/06/2023 |
| 03/02/2023 | Chambers Rebecca | CFO | Payment of Exercise | Common Stock | 2.7k | $24.10 | $65.7k | | 03/02/2023 |
| 03/02/2023 | McGuire Annie | SVP, General Counsel | Payment of Exercise | Common Stock | 2.2k | $24.10 | $51.9k | | 03/02/2023 |
| 03/02/2023 | Stapley Marc | CEO | Payment of Exercise | Common Stock | 6k | $24.10 | $145.3k | | 03/02/2023 |
| 03/02/2023 | Wygant Jonathan | VP, Chief Accounting Officer | Payment of Exercise | Common Stock | 1.2k | $24.10 | $29.5k | | 03/02/2023 |
| 03/02/2023 | Anderson Bonnie H | Director | Payment of Exercise | Common Stock | 9k | $24.10 | $216.8k | | 03/02/2023 |
| 02/28/2023 | EASTHAM KARIN | Director | Sale | Common Stock | 10k | $25.00 | $250k | | 02/28/2023 |
| 02/28/2023 | EASTHAM KARIN | Director | Exercise | Stock Option (right to buy) | 10k | $12.12 | $121.2k | | 02/28/2023 |
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