| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/14/2023 | Prime Medicine, Inc. | | Grant | Stock Option (right to buy) | 39.1k | $14.83 | $579.3k | | 06/14/2023 |
| 06/01/2023 | Denali Therapeutics Inc. | DNLI | Grant | Common Stock | 4.2k | $0.00 | $0 | | 06/01/2023 |
| 06/01/2023 | Denali Therapeutics Inc. | DNLI | Grant | Stock Option (right to buy) | 12.6k | $30.92 | $391.1k | | 06/01/2023 |
| 04/03/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Stock option (right to buy) | 16.4k | $9.05 | $148.1k | | 04/03/2023 |
| 04/03/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 16.4k | $22.85 | $373.9k | | 04/03/2023 |
| 03/13/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 18.3k | $22.47 | $411.9k | | 03/13/2023 |
| 03/13/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 1.7k | $22.72 | $37.9k | | 03/13/2023 |
| 03/13/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Stock option (right to buy) | 20k | $9.05 | $181k | | 03/13/2023 |
| 02/27/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 20k | $25.37 | $507.4k | | 02/27/2023 |
| 02/27/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Stock option (right to buy) | 20k | $9.05 | $181k | | 02/27/2023 |
| 01/17/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 19k | $28.82 | $546.6k | | 01/17/2023 |
| 01/17/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Sale | Common stock | 1k | $29.49 | $30.5k | | 01/17/2023 |
| 01/17/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Stock option (right to buy) | 20k | $9.05 | $181k | | 01/17/2023 |
| 06/21/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock unit | 5k | $0.00 | $0 | | 06/21/2022 |
| 06/21/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock options (right to buy) | 29.3k | $18.09 | $530.2k | | 06/21/2022 |
| 06/02/2022 | Denali Therapeutics Inc. | DNLI | Grant | Common Stock | 6k | $0.00 | $0 | | 06/02/2022 |
| 06/02/2022 | Denali Therapeutics Inc. | DNLI | Grant | Stock Option (right to buy) | 18k | $24.27 | $435.9k | | 06/02/2022 |
| 05/20/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock unit | 1.6k | $0.00 | $0 | | 05/20/2022 |
| 02/22/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 2.8k | $0.00 | $0 | | 02/22/2022 |
| 02/22/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 758 | $29.08 | $22k | | 02/22/2022 |
| 06/02/2021 | Denali Therapeutics Inc. | DNLI | Grant | Common Stock | 2.1k | $0.00 | $0 | | 06/02/2021 |
| 06/02/2021 | Denali Therapeutics Inc. | DNLI | Grant | Stock Option (right to buy) | 6.2k | $63.76 | $396.7k | | 06/02/2021 |
| 06/01/2021 | Denali Therapeutics Inc. | DNLI | Exercise | Restricted Stock Units | 3.3k | $0.00 | $0 | | 06/01/2021 |
| 05/28/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 1.7k | $0.00 | $0 | | 05/28/2021 |
| 05/20/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock options (right to buy) | 8.9k | $56.76 | $504.5k | | 05/20/2021 |
| 05/20/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock unit | 1.6k | $0.00 | $0 | | 05/20/2021 |
| 02/22/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 2.8k | $0.00 | $0 | | 02/22/2021 |
| 02/22/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 821 | $0.00 | $0 | | 02/22/2021 |
| 02/16/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 8.1k | $0.00 | $0 | | 02/16/2021 |
| 02/16/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | Payment of Exercise | Common stock | 2.5k | $0.00 | $0 | | 02/16/2021 |
| 12/21/2020 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 25k | $90.06 | $2.3M | | 12/21/2020 |
| 12/21/2020 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 5k | $90.01 | $450k | See footnote | 12/21/2020 |
| 11/12/2020 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 30k | $70.05 | $2.1M | | 11/12/2020 |
| 11/10/2020 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 10k | $60.03 | $600.3k | | 11/10/2020 |
| 11/04/2020 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 10k | $50.18 | $501.8k | | 11/04/2020 |
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