| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/29/2023 | Spiegel Robert J. | Director | Grant | Common Stock | 3.4k | $0.00 | $0 | | 09/29/2023 |
| 09/29/2023 | Molineaux Susan | Director | Grant | Common Stock | 6.2k | $0.00 | $0 | Family Trust | 09/29/2023 |
| 09/25/2023 | ROBERTSON MICHELLE | EVP, CFO | Grant | Employee Stock Option (right to buy) | 1.4M | $2.17 | $2.9M | | 09/25/2023 |
| 08/24/2023 | O'Farrell Elizabeth G. | Director | Purchase | Common Stock | 6.6k | $2.28 | $15.1k | | 08/24/2023 |
| 08/24/2023 | O'Farrell Elizabeth G. | Director | Purchase | Common Stock | 6.6k | $2.28 | $15k | By Spouse | 08/24/2023 |
| 08/01/2023 | Samuels Scott Alan | EVP, Chief Legal Officer | Grant | Employee Stock Option (right to buy) | 1.4M | $3.21 | $4.3M | | 08/01/2023 |
| 06/30/2023 | Kapur Anil | EVP, Corp Strategy & CCO | Grant | Common Stock | 7.6k | $2.04 | $15.4k | | 06/30/2023 |
| 06/30/2023 | Spiegel Robert J. | Director | Grant | Common Stock | 2.2k | $0.00 | $0 | | 06/30/2023 |
| 06/30/2023 | Molineaux Susan | Director | Grant | Common Stock | 4.1k | $0.00 | $0 | Family Trust | 06/30/2023 |
| 05/31/2023 | LAWLIS V BRYAN | Director | Grant | Stock Option (right to buy) | 125k | $3.27 | $408.8k | | 05/31/2023 |
| 05/31/2023 | McDonald John F | Director | Grant | Stock Options (right to buy) | 125k | $3.27 | $408.8k | | 05/31/2023 |
| 05/31/2023 | Molineaux Susan | Director | Grant | Stock Option (right to buy) | 125k | $3.27 | $408.8k | | 05/31/2023 |
| 05/31/2023 | O'Farrell Elizabeth G. | Director | Grant | Stock Option (right to buy) | 125k | $3.27 | $408.8k | | 05/31/2023 |
| 05/31/2023 | Spiegel Robert J. | Director | Grant | Stock Option (right to buy) | 125k | $3.27 | $408.8k | | 05/31/2023 |
| 05/31/2023 | Bir Dawn Carter | Director | Grant | Stock Option (right to buy) | 125k | $3.27 | $408.8k | | 05/31/2023 |
| 05/11/2023 | LAWLIS V BRYAN | Director | Exercise | Stock Options (right to buy) | 35k | $1.10 | $38.5k | | 05/11/2023 |
| 05/11/2023 | LAWLIS V BRYAN | Director | Sale | Common Stock | 35k | $3.00 | $105k | | 05/11/2023 |
| 03/31/2023 | Spiegel Robert J. | Director | Grant | Common Stock | 3.3k | $0.00 | $0 | | 03/31/2023 |
| 03/31/2023 | Molineaux Susan | Director | Grant | Common Stock | 6k | $0.00 | $0 | Family Trust | 03/31/2023 |
| 02/22/2023 | SCARLETT JOHN A | Chairman, President and CEO | Grant | Employee Stock Option (Right to buy) | 1.8M | $2.83 | $5M | | 02/22/2023 |
| 02/22/2023 | Bloom Olivia Kyusuk | EVP, CFO | Grant | Employee Stock Option (right to buy) | 575k | $2.83 | $1.6M | | 02/22/2023 |
| 02/22/2023 | Feller Faye | EVP, Chief Medical Officer | Grant | Employee Stock Option (right to buy) | 540k | $2.83 | $1.5M | | 02/22/2023 |
| 02/22/2023 | GRETHLEIN ANDREW J | EVP, COO | Grant | Employee Stock Option (right to buy) | 780k | $2.83 | $2.2M | | 02/22/2023 |
| 02/22/2023 | Kapur Anil | EVP, Corp Strategy & CCO | Grant | Employee Stock Option (right to buy) | 625k | $2.83 | $1.8M | | 02/22/2023 |
| 12/30/2022 | Spiegel Robert J. | Director | Grant | Common Stock | 3k | $0.00 | $0 | | 12/30/2022 |
| 12/30/2022 | Kapur Anil | EVP, Corp Strategy & CCO | Grant | Common Stock | 6k | $1.11 | $6.7k | | 12/30/2022 |
| 09/30/2022 | Spiegel Robert J. | Director | Grant | Common Stock | 3.1k | $0.00 | $0 | | 09/30/2022 |
| 09/12/2022 | GRETHLEIN ANDREW J | EVP, COO | Exercise | Employee Stock Option (right to buy) | 2k | $1.70 | $3.4k | | 09/12/2022 |
| 09/12/2022 | GRETHLEIN ANDREW J | EVP, COO | Exercise | Employee Stock Option (right to buy) | 232.7k | $1.70 | $395.6k | | 09/12/2022 |
| 09/07/2022 | McDonald John F | Director | Grant | Stock Options (right to buy) | 200k | $2.72 | $544k | | 09/07/2022 |
| 07/08/2022 | Feller Faye | EVP, Chief Medical Officer | Grant | Employee Stock Option (right to buy) | 120k | $1.93 | $231.6k | | 07/08/2022 |
| 06/30/2022 | Spiegel Robert J. | Director | Grant | Common Stock | 4.6k | $0.00 | $0 | | 06/30/2022 |
| 06/30/2022 | Kapur Anil | EVP, Corp Strategy & CCO | Grant | Common Stock | 13.1k | $1.11 | $14.5k | | 06/30/2022 |
| 05/10/2022 | Bir Dawn Carter | Director | Grant | Stock Option (right to buy) | 125k | $1.48 | $185k | | 05/10/2022 |
| 05/10/2022 | EASTHAM KARIN | Director | Grant | Stock Option (right to buy) | 125k | $1.48 | $185k | | 05/10/2022 |
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