| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/07/2023 | Alkermes plc. | ALKS | Payment of Exercise | Ordinary Shares | 3.1k | $29.88 | $92.6k | | 07/07/2023 |
| 07/07/2023 | Alkermes plc. | ALKS | Exercise | Restricted Stock Unit Award | 6k | $0.00 | $0 | | 07/07/2023 |
| 06/29/2023 | Alkermes plc. | ALKS | Grant | Non Qualified Stock Option (Right to Buy) | 12.7k | $31.33 | $398.9k | | 06/29/2023 |
| 06/29/2023 | Alkermes plc. | ALKS | Grant | Restricted Stock Unit Award | 6k | $0.00 | $0 | | 06/29/2023 |
| 05/17/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Grant | Stock Option (Right to Buy) | 15k | $76.00 | $1.1M | | 05/17/2023 |
| 01/10/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 5k | $52.92 | $264.6k | | 01/10/2023 |
| 01/10/2023 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 5k | $6.41 | $32k | | 01/10/2023 |
| 12/12/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 332 | $58.93 | $19.6k | | 12/12/2022 |
| 12/12/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 781 | $60.08 | $46.9k | | 12/12/2022 |
| 12/12/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 3.9k | $61.41 | $238.7k | | 12/12/2022 |
| 12/12/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 5k | $6.41 | $32k | | 12/12/2022 |
| 11/10/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 255 | $54.20 | $13.8k | | 11/10/2022 |
| 11/10/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 3.9k | $56.14 | $217.3k | | 11/10/2022 |
| 11/10/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 875 | $56.85 | $49.7k | | 11/10/2022 |
| 11/10/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 5k | $6.41 | $32k | | 11/10/2022 |
| 10/10/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 5k | $6.41 | $32k | | 10/10/2022 |
| 10/10/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 2.7k | $56.38 | $150.9k | | 10/10/2022 |
| 10/10/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 2.3k | $55.37 | $128.7k | | 10/10/2022 |
| 09/28/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 10k | $48.09 | $480.9k | | 09/28/2022 |
| 09/28/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 10k | $6.41 | $64.1k | | 09/28/2022 |
| 07/20/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 15k | $32.90 | $493.5k | | 07/20/2022 |
| 07/20/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Exercise | Stock Option (Right to Buy) | 15k | $6.41 | $96.2k | | 07/20/2022 |
| 07/07/2022 | Alkermes plc. | ALKS | Grant | Restricted Stock Unit Award | 6k | $0.00 | $0 | | 07/07/2022 |
| 07/07/2022 | Alkermes plc. | ALKS | Grant | Non Qualified Stock Option (Right to Buy) | 11.6k | $31.48 | $363.7k | | 07/07/2022 |
| 06/14/2022 | Alkermes plc. | ALKS | Exercise | Restricted Stock Unit Award | 7.6k | $0.00 | $0 | | 06/14/2022 |
| 06/14/2022 | Alkermes plc. | ALKS | Payment of Exercise | Ordinary Shares | 3.9k | $27.19 | $107.3k | | 06/14/2022 |
| 05/18/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Grant | Stock Option (Right to Buy) | 15k | $25.60 | $384k | | 05/18/2022 |
| 05/02/2022 | Alkermes plc. | ALKS | Sale | Ordinary Shares | 10k | $29.23 | $292.3k | | 05/02/2022 |
| 05/02/2022 | Alkermes plc. | ALKS | Exercise | Employee Stock Option (Right to Buy) | 10k | $16.55 | $165.5k | | 05/02/2022 |
| 04/25/2022 | Alkermes plc. | ALKS | Sale | Ordinary Shares | 10k | $27.88 | $278.8k | | 04/25/2022 |
| 04/25/2022 | Alkermes plc. | ALKS | Exercise | Employee Stock Option (Right to Buy) | 10k | $16.55 | $165.5k | | 04/25/2022 |
| 04/18/2022 | Alkermes plc. | ALKS | Sale | Ordinary Shares | 10k | $28.88 | $288.8k | | 04/18/2022 |
| 04/18/2022 | Alkermes plc. | ALKS | Exercise | Employee Stock Option (Right to Buy) | 10k | $16.55 | $165.5k | | 04/18/2022 |
| 04/11/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 3k | $34.48 | $103.5k | | 04/11/2022 |
| 04/11/2022 | PROTHENA CORP PUBLIC LTD CO | PRTA | Sale | Ordinary Shares, par value $0.01 per share | 1.5k | $35.76 | $53.1k | | 04/11/2022 |
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