| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/07/2022 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Director Stock Option (right to buy) | 43k | $0.73 | $31.4k | | 06/07/2022 |
| 06/08/2021 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Director Stock Option (right to buy) | 40k | $6.80 | $272k | | 06/08/2021 |
| 06/10/2020 | Flexion Therapeutics Inc | FLXN | Grant | Stock option (right to buy) | 7k | $11.88 | $83.2k | | 06/10/2020 |
| 06/10/2020 | Flexion Therapeutics Inc | FLXN | Grant | Common Stock | 4.5k | $0.00 | $0 | | 06/10/2020 |
| 06/08/2020 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Director Stock Option (right to buy) | 28.1k | $8.89 | $249.8k | | 06/08/2020 |
| 02/28/2020 | Sarepta Therapeutics, Inc. | SRPT | Grant | Common Stock | 6.7k | $0.00 | $0 | | 02/28/2020 |
| 02/28/2020 | Sarepta Therapeutics, Inc. | SRPT | Grant | Stock option (right to buy) | 37.5k | $114.47 | $4.3M | | 02/28/2020 |
| 12/13/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 4.1k | $13.71 | $56.7k | | 12/13/2019 |
| 12/13/2019 | Sarepta Therapeutics, Inc. | SRPT | Sale | Common Stock | 125k | $125.50 | $15.7M | | 12/13/2019 |
| 12/13/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 4.3k | $13.71 | $59.2k | | 12/13/2019 |
| 12/13/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 10.5k | $23.85 | $249.6k | | 12/13/2019 |
| 12/13/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 69.5k | $29.03 | $2M | | 12/13/2019 |
| 12/13/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 21.9k | $32.63 | $713.8k | | 12/13/2019 |
| 12/13/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 14.7k | $34.92 | $514.1k | | 12/13/2019 |
| 08/22/2019 | Sarepta Therapeutics, Inc. | SRPT | Gift | Common Stock | 42.5k | $0.00 | $0 | | 08/21/2019 |
| 08/21/2019 | Sarepta Therapeutics, Inc. | SRPT | Payment of Exercise | Common Stock | 57.5k | $101.50 | $5.8M | | 08/21/2019 |
| 08/21/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock Appreciation Right | 100k | $23.85 | $2.4M | | 08/21/2019 |
| 08/15/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 260 | $13.71 | $3.6k | | 08/15/2019 |
| 08/15/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 2.9k | $34.92 | $100k | | 08/15/2019 |
| 08/15/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 3k | $29.03 | $87.7k | | 08/15/2019 |
| 08/15/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 2.6k | $13.90 | $36.5k | | 08/15/2019 |
| 08/15/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 985 | $13.71 | $13.5k | | 08/15/2019 |
| 06/19/2019 | Flexion Therapeutics Inc | FLXN | Grant | Stock option (right to buy) | 12.5k | $11.74 | $146.8k | | 06/19/2019 |
| 06/07/2019 | Aeglea BioTherapeutics, Inc. | AGLE | Grant | Director Stock Option (right to buy) | 12.4k | $6.33 | $78.5k | | 06/07/2019 |
| 03/28/2019 | Sarepta Therapeutics, Inc. | SRPT | Grant | Common Stock | 6.6k | $0.00 | $0 | | 03/28/2019 |
| 03/28/2019 | Sarepta Therapeutics, Inc. | SRPT | Payment of Exercise | Common Stock | 3k | $118.68 | $350.5k | | 03/28/2019 |
| 03/19/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 3.5k | $13.90 | $48.8k | | 03/19/2019 |
| 03/19/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 164 | $13.71 | $2.2k | | 03/19/2019 |
| 03/19/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 43 | $13.71 | $589.5 | | 03/19/2019 |
| 03/19/2019 | Sarepta Therapeutics, Inc. | SRPT | Payment of Exercise | Common Stock | 2.6k | $126.47 | $332k | | 03/19/2019 |
| 03/19/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock option (right to buy) | 11.8k | $23.85 | $280.7k | | 03/19/2019 |
| 03/04/2019 | Sarepta Therapeutics, Inc. | SRPT | Grant | Stock option (right to buy) | 55k | $145.48 | $8M | | 02/28/2019 |
| 02/28/2019 | Sarepta Therapeutics, Inc. | SRPT | Disposition | Common Stock | 4.8k | $0.00 | $0 | | 02/28/2019 |
| 02/07/2019 | Sarepta Therapeutics, Inc. | SRPT | Exercise | Stock Option (right to buy) | 65k | $23.85 | $1.6M | | 02/07/2019 |
| 02/07/2019 | Sarepta Therapeutics, Inc. | SRPT | Sale | Common Stock | 65k | $145.00 | $9.4M | | 02/07/2019 |
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