| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Option (Right to Buy) | 47k | $6.40 | $300.8k | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Option (Right to Buy) | 81k | $6.02 | $487.6k | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Option (Right to Buy) | 75k | $4.09 | $306.8k | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Option (Right to Buy) | 75k | $1.30 | $97.5k | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Option (Right to Buy) | 60k | $3.42 | $205.2k | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Option (Right to Buy) | 47k | $6.57 | $308.8k | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Restricted Stock Unit | 4.5k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Restricted Stock Unit | 22.2k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Restricted Stock Unit | 15k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | CREAGER STEPHEN E | Sr. VP and General Counsel | Disposition | Restricted Stock Unit | 16k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Common Stock | 423.2k | $10.50 | $4.4M | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 20k | $6.86 | $137.2k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 37k | $6.40 | $236.8k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 65k | $6.02 | $391.3k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 75k | $4.09 | $306.8k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 30k | $2.97 | $89.1k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 75k | $1.30 | $97.5k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 60k | $3.42 | $205.2k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Option (Right to Buy) | 58k | $6.57 | $381.1k | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Restricted Stock Unit | 4.5k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Restricted Stock Unit | 22.2k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Restricted Stock Unit | 15k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | Manyak David M | Exec VP, Drug Discovery Svcs | Disposition | Restricted Stock Unit | 19k | $0.00 | $0 | | 11/07/2011 |
| 11/07/2011 | Griffith Joseph H. IV | VP, Finance & Controller | Disposition | Common Stock | 33.3k | $10.50 | $349.5k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 47k | $6.40 | $300.8k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 81k | $6.02 | $487.6k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 75k | $4.09 | $306.8k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 30k | $2.97 | $89.1k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Common Stock | 82.2k | $10.50 | $863.5k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 100k | $7.71 | $771k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 50k | $3.63 | $181.5k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 30k | $3.78 | $113.4k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 22k | $5.85 | $128.7k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 12k | $6.25 | $75k | | 11/07/2011 |
| 11/07/2011 | KRUKA WILLIAM C. | Sr VP Corporate Development | Disposition | Option (Right to Buy) | 75k | $1.30 | $97.5k | | 11/07/2011 |
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