| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/10/2023 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 225k | $1.36 | $306k | | 08/10/2023 |
| 06/12/2023 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 350k | $1.46 | $511k | | 06/12/2023 |
| 03/23/2023 | Metacrine, Inc. | MTCR | Disposition | Stock Option (right to buy) | 842.2k | $0.47 | $395.8k | | 03/23/2023 |
| 03/23/2023 | Metacrine, Inc. | MTCR | Grant | Common Stock | 842.2k | $0.47 | $395.8k | | 03/23/2023 |
| 01/26/2023 | Metacrine, Inc. | MTCR | Sale | Common Stock | 380.6k | $0.41 | $157.3k | | 01/26/2023 |
| 04/19/2022 | Metacrine, Inc. | MTCR | Sale | Common Stock | 43.6k | $0.50 | $21.9k | | 04/19/2022 |
| 04/19/2022 | Metacrine, Inc. | MTCR | Sale | Common Stock | 1.2k | $0.51 | $593.1 | | 04/19/2022 |
| 04/14/2022 | Metacrine, Inc. | MTCR | Grant | Common Stock | 104.5k | $0.00 | $0 | | 04/14/2022 |
| 02/27/2022 | Metacrine, Inc. | MTCR | Grant | Common Stock | 842.2k | $0.00 | $0 | | 02/27/2022 |
| 02/27/2022 | Metacrine, Inc. | MTCR | Grant | Stock option (right to buy) | 842.2k | $0.47 | $395.8k | | 02/27/2022 |
| 05/20/2021 | Metacrine, Inc. | MTCR | Purchase | Common Stock | 20.5k | $3.64 | $74.7k | | 05/20/2021 |
| 02/10/2021 | Metacrine, Inc. | MTCR | Grant | Stock Option (Right to Buy) | 247.5k | $10.09 | $2.5M | | 02/10/2021 |
| 03/01/2020 | ARENA PHARMACEUTICALS INC | ARNA | Grant | Employee Stock Option (right to buy) | 70k | $44.60 | $3.1M | | 03/01/2020 |
| 10/14/2019 | ARENA PHARMACEUTICALS INC | ARNA | Payment of Exercise | Common Stock | 2.3k | $47.32 | $109.3k | | 10/14/2019 |
| 10/14/2019 | ARENA PHARMACEUTICALS INC | ARNA | Exercise | Performance Restricted Stock Unit | 6.3k | $0.00 | $0 | | 10/14/2019 |
| 06/27/2019 | Histogen Inc. | CNAT | Grant | Stock Option (Right to Buy) | 20k | $0.29 | $5.8k | | 06/27/2019 |
| 01/08/2019 | ARENA PHARMACEUTICALS INC | ARNA | Exercise | Employee Stock Option (right to buy) | 3k | $15.10 | $45.3k | | 01/04/2019 |
| 01/08/2019 | ARENA PHARMACEUTICALS INC | ARNA | Sale | Common Stock | 3k | $44.00 | $132k | | 01/04/2019 |
| 01/07/2019 | ARENA PHARMACEUTICALS INC | ARNA | Sale | Common Stock | 400 | $42.32 | $16.9k | | 01/04/2019 |
| 01/07/2019 | ARENA PHARMACEUTICALS INC | ARNA | Sale | Common Stock | 15.6k | $41.68 | $650.1k | | 01/04/2019 |
| 01/07/2019 | ARENA PHARMACEUTICALS INC | ARNA | Exercise | Employee Stock Option (right to buy) | 16k | $15.10 | $241.6k | | 01/04/2019 |
| 01/04/2019 | ARENA PHARMACEUTICALS INC | ARNA | Grant | Employee Performance Restricted Stock Unit | 12.6k | $0.00 | $0 | | 01/04/2019 |
| 01/04/2019 | ARENA PHARMACEUTICALS INC | ARNA | Grant | Employee Stock Option (right to buy) | 75k | $40.94 | $3.1M | | 01/04/2019 |
| 06/21/2018 | Histogen Inc. | CNAT | Grant | Stock Option (Right to Buy) | 20k | $4.99 | $99.8k | | 06/21/2018 |
| 01/19/2018 | ARENA PHARMACEUTICALS INC | ARNA | Grant | Employee Stock Option (right to buy) | 130k | $35.60 | $4.6M | | 01/19/2018 |
| 06/22/2017 | Histogen Inc. | CNAT | Grant | Stock Option (Right to Buy) | 20k | $4.96 | $99.2k | | 06/22/2017 |
| 03/20/2017 | ARENA PHARMACEUTICALS INC | ARNA | Grant | Employee Stock Option (right to buy | 1.3M | $1.50 | $1.9M | | 03/20/2017 |
| 06/23/2016 | Histogen Inc. | CNAT | Grant | Stock Option (Right to Buy) | 20k | $2.13 | $42.6k | | 06/23/2016 |
| 07/25/2011 | Orexigen Therapeutics, Inc. | OREXQ | Grant | Stock Option (right to buy) | 832k | $1.66 | $1.4M | | 07/22/2011 |
| 07/22/2011 | Orexigen Therapeutics, Inc. | OREXQ | Disposition | Stock Option (right to buy) | 200k | $7.52 | $1.5M | | 07/22/2011 |
| 07/22/2011 | Orexigen Therapeutics, Inc. | OREXQ | Disposition | Stock Option (right to buy) | 30k | $6.74 | $202.2k | | 07/22/2011 |
| 07/22/2011 | Orexigen Therapeutics, Inc. | OREXQ | Disposition | Stock Option (right to buy) | 45k | $2.94 | $132.3k | | 07/22/2011 |
| 07/22/2011 | Orexigen Therapeutics, Inc. | OREXQ | Disposition | Stock Option (right to buy) | 107k | $2.94 | $314.6k | | 07/22/2011 |
| 07/22/2011 | Orexigen Therapeutics, Inc. | OREXQ | Disposition | Stock Option (right to buy) | 450k | $1.70 | $765k | | 07/22/2011 |