| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/26/2023 | Frequency Therapeutics, Inc. | FREQ | Grant | Restricted Stock Unit | 91k | $0.00 | $0 | | 01/26/2023 |
| 08/17/2022 | Frequency Therapeutics, Inc. | FREQ | Grant | Stock Option | 178.9k | $2.14 | $382.9k | | 08/17/2022 |
| 08/17/2022 | Frequency Therapeutics, Inc. | FREQ | Disposition | Stock Option | 178.9k | $14.00 | $2.5M | | 08/17/2022 |
| 08/17/2022 | Frequency Therapeutics, Inc. | FREQ | Grant | Stock Option | 75k | $2.14 | $160.5k | | 08/17/2022 |
| 08/17/2022 | Frequency Therapeutics, Inc. | FREQ | Disposition | Stock Option | 75k | $35.85 | $2.7M | | 08/17/2022 |
| 08/17/2022 | Frequency Therapeutics, Inc. | FREQ | Grant | Stock Option | 57.5k | $2.14 | $123k | | 08/17/2022 |
| 08/17/2022 | Frequency Therapeutics, Inc. | FREQ | Disposition | Stock Option | 57.5k | $25.05 | $1.4M | | 08/17/2022 |
| 07/06/2022 | Frequency Therapeutics, Inc. | FREQ | Sale | Common Stock | 4.4k | $1.52 | $6.7k | | 07/05/2022 |
| 07/05/2022 | Frequency Therapeutics, Inc. | FREQ | Exercise | Restricted Stock Unit | 15k | $0.00 | $0 | | 07/05/2022 |
| 02/22/2022 | Frequency Therapeutics, Inc. | FREQ | Sale | Common Stock | 1.1k | $3.53 | $3.8k | | 02/18/2022 |
| 02/18/2022 | Frequency Therapeutics, Inc. | FREQ | Sale | Common Stock | 974 | $3.87 | $3.8k | | 02/18/2022 |
| 02/17/2022 | Frequency Therapeutics, Inc. | FREQ | Grant | Restricted Stock Unit | 150k | $0.00 | $0 | | 02/16/2022 |
| 02/17/2022 | Frequency Therapeutics, Inc. | FREQ | Sale | Common Stock | 901 | $4.19 | $3.8k | | 02/16/2022 |
| 02/16/2022 | Frequency Therapeutics, Inc. | FREQ | Sale | Common Stock | 831 | $4.43 | $3.7k | | 02/16/2022 |
| 02/15/2022 | Frequency Therapeutics, Inc. | FREQ | Sale | Common Stock | 844 | $4.33 | $3.7k | | 02/14/2022 |
| 02/14/2022 | Frequency Therapeutics, Inc. | FREQ | Exercise | Restricted Stock Unit | 15k | $0.00 | $0 | | 02/14/2022 |
| 04/20/2021 | Frequency Therapeutics, Inc. | FREQ | Grant | Restricted Stock Unit | 30k | $0.00 | $0 | | 04/20/2021 |
| 01/15/2021 | Frequency Therapeutics, Inc. | FREQ | Grant | Stock Option | 75k | $35.85 | $2.7M | | 01/15/2021 |
| 02/12/2020 | Frequency Therapeutics, Inc. | FREQ | Grant | Stock Option | 57.5k | $25.05 | $1.4M | | 02/12/2020 |
| 12/03/2019 | Frequency Therapeutics, Inc. | FREQ | Grant | Stock Option | 23.6k | $3.37 | $79.4k | | 12/03/2019 |
| 10/02/2019 | Frequency Therapeutics, Inc. | FREQ | Grant | Stock Option | 178.9k | $14.00 | $2.5M | | 10/02/2019 |
| 04/17/2019 | Frequency Therapeutics, Inc. | FREQ | Grant | | 23.6k | $3.37 | $79.4k | | 10/02/2019 |
| 04/17/2019 | Frequency Therapeutics, Inc. | FREQ | Grant | | 101.9k | $3.37 | $343.5k | | 10/02/2019 |
| 11/21/2016 | OTONOMY, INC. | OTIC | Sale | Common Stock | 1.5k | $18.07 | $26.3k | | 11/18/2016 |
| 11/21/2016 | OTONOMY, INC. | OTIC | Exercise | Employee Stock Option (right to buy) | 1.5k | $3.17 | $4.6k | | 11/18/2016 |
| 11/18/2016 | OTONOMY, INC. | OTIC | Exercise | Employee Stock Option (right to buy) | 3.5k | $6.33 | $22.4k | | 11/18/2016 |
| 11/18/2016 | OTONOMY, INC. | OTIC | Exercise | Employee Stock Option (right to buy) | 5.6k | $3.17 | $17.8k | | 11/18/2016 |
| 11/18/2016 | OTONOMY, INC. | OTIC | Sale | Common Stock | 9.2k | $18.07 | $165.7k | | 11/18/2016 |
| 09/06/2016 | OTONOMY, INC. | OTIC | Exercise | Employee Stock Option (right to buy) | 5.3k | $3.17 | $16.8k | | 09/06/2016 |
| 09/06/2016 | OTONOMY, INC. | OTIC | Exercise | Employee Stock Option (right to buy) | 15.9k | $6.33 | $100.9k | | 09/06/2016 |
| 09/06/2016 | OTONOMY, INC. | OTIC | Sale | Common Stock | 5.3k | $17.95 | $95.2k | | 09/06/2016 |
| 09/06/2016 | OTONOMY, INC. | OTIC | Sale | Common Stock | 3.8k | $17.95 | $68.4k | | 09/06/2016 |
| 09/06/2016 | OTONOMY, INC. | OTIC | Sale | Common Stock | 12.1k | $17.95 | $217.8k | | 09/06/2016 |
| 06/01/2016 | OTONOMY, INC. | OTIC | Grant | Common Stock | 275 | $13.13 | $3.6k | | 09/06/2016 |
| 03/01/2016 | OTONOMY, INC. | OTIC | Grant | Employee Stock Option (right to buy) | 35k | $14.44 | $505.4k | | 03/01/2016 |
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