| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 771 | $184.70 | $142.4k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.9k | $185.54 | $346.8k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.1k | $186.39 | $206.3k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 101 | $187.37 | $18.9k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 17 | $188.40 | $3.2k | | 08/03/2023 |
| 08/04/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 192 | $189.31 | $36.3k | | 08/03/2023 |
| 08/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 5.1k | $0.00 | $0 | | 08/03/2023 |
| 08/03/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.9k | $0.00 | $0 | | 08/03/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 197 | $193.18 | $38.1k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 910 | $193.93 | $176.5k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1k | $194.94 | $197.5k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 104 | $195.65 | $20.3k | | 04/26/2023 |
| 04/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 168 | $197.08 | $33.1k | | 04/26/2023 |
| 04/26/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 5.3k | $0.00 | $0 | | 04/26/2023 |
| 02/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Restricted Stock Units | 5.8k | $0.00 | $0 | | 02/27/2023 |
| 02/27/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 12k | $190.01 | $2.3M | | 02/27/2023 |
| 02/10/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 30.9k | $63.00 | $1.9M | | 02/10/2023 |
| 02/10/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 4.3k | $217.05 | $933.7k | | 02/10/2023 |
| 02/10/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 19.4k | $216.38 | $4.2M | | 02/10/2023 |
| 02/10/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 10.3k | $215.59 | $2.2M | | 02/10/2023 |
| 02/10/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 2.3k | $214.28 | $494.3k | | 02/10/2023 |
| 02/10/2023 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Sale | Common Stock | 1.7k | $213.13 | $364.2k | | 02/10/2023 |
| 12/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 1.3k | $226.20 | $299.5k | | 12/05/2022 |
| 12/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 2.4k | $42.22 | $100k | | 12/05/2022 |
| 12/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 1.6k | $63.00 | $100k | | 12/05/2022 |
| 12/05/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 1.1k | $88.95 | $100k | | 12/05/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 198 | $210.75 | $41.7k | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 5.5k | $189.76 | $1M | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 195 | $210.22 | $41k | | 08/03/2022 |
| 08/04/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 180 | $210.66 | $37.9k | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 5.1k | $0.00 | $0 | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 4.2k | $0.00 | $0 | | 08/03/2022 |
| 08/03/2022 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 3.9k | $0.00 | $0 | | 08/03/2022 |
| 06/16/2022 | Scholar Rock Holding Corp | SRRK | Grant | Stock Option (Right to Buy) | 14k | $4.86 | $68k | | 06/16/2022 |
| 06/09/2022 | Editas Medicine, Inc. | EDIT | Grant | Stock Option (right to buy) | 25k | $12.31 | $307.8k | | 06/09/2022 |
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