| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/29/2017 | BRANDT GORDON | Chief Medical Officer | Grant | Employee Stock Option (right to buy) | 55k | $0.95 | $52.2k | | 06/29/2017 |
| 05/25/2017 | ATWOOD BRIAN G | 10% Owner | Grant | Employee Stock Option (right to buy) | 14k | $1.08 | $15.1k | | 05/25/2017 |
| 05/25/2017 | GRIFFIN MICHELLE RENEE | Director | Grant | Employee Stock Option (right to buy) | 14k | $1.08 | $15.1k | | 05/25/2017 |
| 05/25/2017 | JOHNSON PAUL H | Director | Grant | Employee Stock Option (right to buy) | 14k | $1.08 | $15.1k | | 05/25/2017 |
| 05/25/2017 | Schmidt John A Jr | Director | Grant | Employee Stock Option (right to buy) | 14k | $1.08 | $15.1k | | 05/25/2017 |
| 05/25/2017 | GILLIS STEVEN | 10% Owner | Grant | Employee Stock Option (right to buy) | 14k | $1.08 | $15.1k | | 05/25/2017 |
| 05/25/2017 | Phillips Peggy V | Director | Grant | Employee Stock Option (right to buy) | 14k | $1.08 | $15.1k | | 05/25/2017 |
| 12/31/2016 | Houston Michael | Chief Scientific Officer | Grant | Employee Stock Option (right to buy) | 35k | $1.45 | $50.8k | | 12/31/2016 |
| 12/31/2016 | OVERELL ROBERT W | President and CEO | Grant | Employee Stock Option (right to buy) | 100k | $1.45 | $145k | | 12/31/2016 |
| 12/31/2016 | Tsui Shing-Yin | Senior VP, Finance, Secretary | Grant | Employee Stock Option (right to buy) | 20k | $1.45 | $29k | | 12/31/2016 |
| 12/31/2016 | BRANDT GORDON | Chief Medical Officer | Grant | Employee Stock Option (right to buy) | 20k | $1.45 | $29k | | 12/31/2016 |
| 08/19/2016 | BRANDT GORDON | Chief Medical Officer | Grant | Employee Stock Option (right to buy) | 125k | $3.16 | $395k | | 08/19/2016 |
| 07/01/2016 | Tsui Shing-Yin | Senior VP, Finance, Secretary | Grant | Employee Stock Option (right to buy) | 50k | $4.29 | $214.5k | | 07/01/2016 |
| 06/01/2016 | Tsui Shing-Yin | Senior VP, Finance, Secretary | Grant | Employee Stock Option (right to buy) | 16.9k | $5.08 | $85.9k | | 06/01/2016 |
| 06/01/2016 | GRIFFIN MICHELLE RENEE | Director | Grant | Employee Stock Option (right to buy) | 13.6k | $5.08 | $69.2k | | 06/01/2016 |
| 06/01/2016 | JOHNSON PAUL H | Director | Grant | Employee Stock Option (right to buy) | 28.2k | $5.08 | $143.3k | | 06/01/2016 |
| 06/01/2016 | Houston Michael | Chief Scientific Officer | Grant | Employee Stock Option (right to buy) | 52.3k | $5.08 | $265.5k | | 06/01/2016 |
| 06/01/2016 | OVERELL ROBERT W | President and CEO | Grant | Employee Stock Option (right to buy) | 196.3k | $5.08 | $997.3k | | 06/01/2016 |
| 06/01/2016 | GILLIS STEVEN | 10% Owner | Grant | Employee Stock Option (right to buy) | 31k | $5.08 | $157.6k | | 06/01/2016 |
| 06/01/2016 | ATWOOD BRIAN G | 10% Owner | Grant | Employee Stock Option (right to buy) | 28.2k | $5.08 | $143.3k | | 06/01/2016 |
| 05/23/2016 | ATWOOD BRIAN G | 10% Owner | Sale | Common Stock | 435 | $0.01 | $4.4 | By Versant Side Fund III, L.P. | 05/23/2016 |
| 05/23/2016 | ATWOOD BRIAN G | 10% Owner | Sale | Common Stock | 1.1k | $0.01 | $10.8 | By Versant Side Fund III, L.P. | 05/23/2016 |
| 05/23/2016 | ATWOOD BRIAN G | 10% Owner | Purchase | Common Stock | 3.5k | $5.00 | $17.6k | By Versant Side Fund III, L.P. | 05/23/2016 |
| 05/23/2016 | ATWOOD BRIAN G | 10% Owner | Sale | Common Stock | 73.6k | $0.01 | $736.2 | By Versant Venture Capital III, L.P. | 05/23/2016 |
| 05/23/2016 | ATWOOD BRIAN G | 10% Owner | Sale | Common Stock | 182.9k | $0.01 | $1.8k | By Versant Venture Capital III, L.P. | 05/23/2016 |
| 05/23/2016 | ATWOOD BRIAN G | 10% Owner | Purchase | Common Stock | 596.5k | $5.00 | $3M | By Versant Venture Capital III, L.P. | 05/23/2016 |
| 05/23/2016 | GILLIS STEVEN | 10% Owner | Sale | Common Stock | 484.9k | $0.01 | $4.8k | By ARCH Venture Fund VII, L.P. | 05/23/2016 |
| 05/23/2016 | GILLIS STEVEN | 10% Owner | Sale | Common Stock | 195.2k | $0.01 | $2k | By ARCH Venture Fund VII, L.P. | 05/23/2016 |
| 05/23/2016 | GILLIS STEVEN | 10% Owner | Purchase | Common Stock | 1000k | $5.00 | $5M | By ARCH Venture Fund VII, L.P. | 05/23/2016 |
| 05/23/2016 | GILLIS STEVEN | 10% Owner | Grant | Employee Stock Option(right to buy) | 9.4k | $1.81 | $17k | | 05/23/2016 |
| 05/23/2016 | Ulevitch Richard J | Director | Sale | Common Stock | 125.8k | $0.01 | $1.3k | By 5AM Ventures II, LP | 05/23/2016 |
| 05/23/2016 | Ulevitch Richard J | Director | Sale | Common Stock | 312.6k | $0.01 | $3.1k | By 5AM Ventures II, LP | 05/23/2016 |
| 05/23/2016 | Ulevitch Richard J | Director | Purchase | Common Stock | 96.2k | $5.00 | $481k | By 5AM Ventures II, LP | 05/23/2016 |
| 05/23/2016 | Ulevitch Richard J | Director | Sale | Common Stock | 5k | $0.01 | $49.6 | By 5AM Co-Investors II, LP | 05/23/2016 |
| 05/23/2016 | Ulevitch Richard J | Director | Sale | Common Stock | 12.3k | $0.01 | $123.4 | By 5AM Co-Investors II, LP | 05/23/2016 |
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