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| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Total revenues, net | 194.1 | 83.1 | 69.9 | 24.2 | | | | |
| Total revenues, net growth | 133.5% | 19.0% | 189.0% | | | | | |
| Costs and expenses: | | | | | | | | |
| Cost of goods sold | 26.8 | 25.3 | 4.8 | 0.6 | | | | |
| Selling, general, and administrative | 137.8 | 137.2 | 138.4 | 120.6 | 56.9 | 34.7 | 30.6 | 20.1 |
| Research and development | 75.8 | 74.0 | 91.4 | 86.1 | 72.1 | 52.4 | 44.5 | 29.9 |
| Total costs and expenses | 240.5 | 238.8 | 257.4 | 233.9 | 145.7 | 96.9 | | |
| Loss from operations | -46.4 | -155.7 | -187.5 | -209.7 | -145.7 | -96.9 | -75.1 | -50.0 |
| Operating margin | -23.9% | -187.3% | -268.3% | -867.4% | | | | |
| Other expense, net | -27.9 | -22.2 | -12.2 | -22.8 | -1.2 | -2.0 | 0.9 | 1.8 |
| Loss before income taxes | -74.2 | -177.9 | -199.7 | -232.6 | -146.9 | -98.9 | -74.2 | -48.1 |
| Income tax expense | 0.6 | 5.2 | -0.1 | 0.0 | -1.8 | 0.2 | 0.1 | |
| Net loss | -74.8 | -183.1 | -199.6 | -232.6 | -145.1 | -99.1 | -74.4 | -48.1 |
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| Net loss per common share—basic (in dollars per share) | ($1.61) | ($3.99) | ($4.39) | ($5.58) | ($4.11) | ($3.40) | ($2.88) | ($2.00) |
| Net loss per common share—diluted (in dollars per share) | ($1.61) | ($3.99) | ($4.39) | ($5.58) | ($4.11) | ($3.40) | ($2.88) | ($2.00) |
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| Weighted average number of common shares outstanding—basic (in shares) | 46.3 | 45.9 | 45.4 | 41.7 | 35.3 | 29.1 | 25.8 | 24.1 |
| Weighted average number of common shares outstanding—diluted (in shares) | 46.3 | 45.9 | 45.4 | | | | | |
| Net loss | -74.8 | -183.1 | -199.6 | -232.6 | -145.1 | -99.1 | -74.4 | -48.1 |
| Comprehensive loss | -74.9 | -183.1 | -199.7 | -232.5 | -145.1 | -98.9 | -74.4 | |
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| Revenue from Contract with Customer, Product and Service [Extensible Enumeration] | | | | | | | | |
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