| In millions, except per share items | Dec-31-22 | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 10-K | 10-K | 10-K | 10-K | 10-K/A | 10-K | 10-K | 10-K |
| Revenues: |
| Other | | | | | | | 20.6 | 23.8 |
| MID | | | | | | | 239.8 | 222.0 |
| Other | | | | | | | 76.2 | 50.5 |
| Total revenues [+] | 454.8 | 328.3 | 246.3 | 227.6 | 231.2 | 393.1 | 336.6 | 296.3 |
| Royalties | | | | | | | | 262.4 |
| Products | | | | | | | | 17.3 |
| Contracts | | | | | | | | 16.5 |
| Revenue growth [+] | 38.5% | 33.3% | 8.2% | -1.6% | -41.2% | 16.8% | 13.6% | -0.1% |
| Other | | | | | | | -13.6% | 13.8% |
| MID | | | | | | | 8.1% | -1.9% |
| Cost of goods sold [+] | 107.6 | 70.4 | 60.7 | 51.4 | 53.7 | 55.4 | 45.8 | 33.0 |
| Cost of product sales | 89.0 | 49.4 | 37.7 | 27.2 | 18.3 | | | 12.4 |
| Amortization of intangibles | 13.9 | 16.2 | 17.4 | | | | | |
| Gross profit | 347.2 | 257.9 | 185.6 | 176.2 | 177.5 | 337.7 | 290.8 | 263.3 |
| Gross margin | 76.3% | 78.6% | 75.3% | 77.4% | 76.8% | 85.9% | 86.4% | 88.9% |
| Selling, general and administrative | 106.7 | 91.1 | 86.4 | 100.6 | 98.3 | 110.9 | 95.1 | 70.6 |
| Research and development | 158.8 | 135.7 | 139.8 | 156.8 | 158.3 | 149.1 | 129.8 | 111.1 |
| Other operating expenses | | | | | | 23.8 | 21.3 | 12.4 |
| EBITDA [+] | 127.2 | 74.2 | 6.4 | -43.2 | -49.8 | | 94.6 | 106.7 |
| EBITDA growth | 71.3% | 1056.0% | -114.9% | -13.2% | -151.9% | 1.3% | -11.3% | -3.0% |
| EBITDA margin | 28.0% | 22.6% | 2.6% | -19.0% | -21.5% | 24.4% | 28.1% | 36.0% |
| Depreciation | 31.5 | 26.8 | 29.8 | 23.6 | 5.7 | | 13.0 | 12.4 |
| EBITA | 95.7 | 47.4 | -23.4 | -66.8 | -55.4 | 95.8 | 81.7 | 94.3 |
| EBITA margin | 21.0% | 14.4% | -9.5% | -29.4% | -24.0% | 24.4% | 24.3% | 31.8% |
| Amortization of intangibles | 15.6 | 17.5 | 18.4 | 17.1 | 29.3 | 42.0 | 37.1 | 25.1 |
| EBIT [+] | 80.1 | 29.9 | -41.8 | -83.9 | -84.8 | 53.9 | 44.5 | 69.3 |
| EBIT growth | 167.3% | -171.7% | -50.2% | -1.0% | -257.3% | 21.0% | -35.7% | -0.8% |
| EBIT margin | 17.6% | 9.1% | -17.0% | -36.9% | -36.7% | 13.7% | 13.2% | 23.4% |
| Non-recurring items [+] | 3.1 | 5.7 | 2.3 | 16.3 | 2.2 | -0.5 | 10.9 | -2.2 |
| Asset impairment | | | | | | | 18.3 | |
| Loss (gain) on sale of assets | | | | | | -0.5 | | -3.7 |
| Loss (gain) on disposal of assets | | | | 7.4 | | | | |
| Legal settlement | | | | | | | -0.6 | -2.0 |
| Loss on contingent liability | 3.1 | 5.3 | -1.8 | | | | -6.8 | |
| Interest expense | 1.9 | 10.7 | 10.3 | 9.9 | 16.3 | 13.7 | 12.7 | 12.4 |
| Interest expense | 1.9 | 10.7 | 10.3 | 9.9 | 16.3 | 13.7 | 12.7 | 12.4 |
| Other income (expense), net [+] | -82.9 | 9.7 | 17.9 | 27.4 | 32.6 | 0.3 | 1.7 | 1.2 |
| Gain (loss) on debt retirement | -83.6 | | | | | -1.1 | | |
| Other non-operating income | 7.8 | 9.7 | 17.9 | | | | | |
| Other | -7.8 | -9.7 | -17.9 | | | | | |
| Pre-tax income | -7.8 | 23.3 | -36.5 | -82.5 | -70.6 | 41.0 | 22.6 | 60.2 |
| Income taxes | 6.5 | 5.0 | 3.9 | 3.4 | 87.3 | 63.9 | 15.8 | -151.2 |
| Tax rate | | 21.3% | | | | 155.8% | 69.9% | |
| Net income | -14.3 | 18.3 | -40.5 | -86.0 | -158.0 | -22.9 | 6.8 | 211.4 |
| Net margin | -3.1% | 5.6% | -16.4% | -37.8% | -68.3% | -5.8% | 2.0% | 71.3% |
| |
| Basic EPS [+] | ($0.13) | $0.17 | ($0.36) | ($0.77) | ($1.46) | ($0.21) | $0.06 | $1.84 |
| Growth | -178.8% | -146.4% | -53.9% | -46.8% | 602.1% | -435.1% | -96.6% | 703.3% |
| Diluted EPS [+] | ($0.13) | $0.16 | ($0.36) | ($0.77) | ($1.46) | ($0.21) | $0.06 | $1.80 |
| Growth | -181.9% | -144.7% | -53.9% | -46.8% | 602.1% | -444.2% | -96.6% | 707.8% |
| |
| Shares outstanding (basic) [+] | 109.5 | 110.5 | 113.3 | 110.9 | 108.5 | 110.2 | 110.2 | 114.8 |
| Growth | -1.0% | -2.4% | 2.1% | 2.3% | -1.6% | 0.0% | -4.1% | 0.4% |
| Shares outstanding (diluted) [+] | 109.5 | 114.9 | 113.3 | 110.9 | 108.5 | 110.2 | 113.1 | 117.5 |
| Growth | -4.7% | 1.4% | 2.1% | 2.3% | -1.6% | -2.6% | -3.7% | -0.1% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |