| In millions, except per share items | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 | Dec-31-13 | Dec-31-12 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Collaboration revenue | | | | | | | 1.6 | 8.5 |
| Royalty income | | | | | 6.6 | 3.1 | 5.9 | 5.0 |
| License revenue | | | | | 2.0 | 41.2 | | |
| Other | | | | | 0.1 | 0.1 | 0.3 | 0.6 |
| Total revenues [+] | 35.0 | 15.6 | 11.7 | 69.4 | 8.7 | 44.4 | 7.9 | 14.0 |
| Licensing | | | | | 2.0 | 41.2 | 1.6 | 8.5 |
| Royalties | | | | | 6.6 | 3.1 | 5.9 | 5.0 |
| Grants | | | | | | | 0.3 | 0.5 |
| Other | | | | | 0.1 | 0.1 | 0.1 | 0.1 |
| Revenue growth [+] | 124.0% | 33.5% | -83.2% | 700.2% | -80.4% | 464.4% | -44.0% | -83.4% |
| Collaboration revenue | | | | | | | -81.3% | |
| Royalty income | | | | | 113.1% | -47.6% | 19.3% | 62.9% |
| License revenue | | | | | -95.3% | | | |
| Cost of goods sold | 3.2 | 82.0 | 2.6 | -60.9 | 0.0 | -61.3 | -51.0 | 1.2 |
| Gross profit | 31.8 | -66.4 | 9.1 | 130.4 | 8.7 | 105.6 | 58.9 | 12.9 |
| Gross margin | 90.9% | -424.8% | 77.8% | 187.8% | 100.0% | 238.0% | 749.2% | 91.7% |
| Selling, general and administrative [+] | 47.8 | 29.4 | 24.9 | 23.4 | 18.2 | 15.5 | 15.5 | 15.2 |
| General and administrative | | | | | 18.2 | 15.5 | 15.5 | 15.2 |
| Research and development | 49.2 | 35.1 | 42.6 | 37.6 | 28.2 | 28.6 | 34.6 | 31.3 |
| Equity in earnings | | | | | | | | |
| Other operating expenses | | -82.0 | -2.6 | 60.9 | 1.6 | 55.5 | 50.8 | 0.5 |
| EBITDA [+] | -62.9 | -47.5 | -54.7 | 10.6 | -38.7 | 6.6 | -41.1 | -34.2 |
| EBITDA growth | 32.5% | -13.2% | -616.7% | -127.3% | -687.8% | -116.0% | 20.4% | -375.9% |
| EBITDA margin | -179.7% | -303.8% | -467.4% | 15.2% | -446.5% | 14.9% | -523.0% | -243.2% |
| Depreciation | 1.3 | 1.0 | 0.9 | 1.9 | 0.6 | 0.5 | 0.9 | 1.3 |
| EBITA | -64.1 | -48.5 | -55.6 | 8.7 | -39.3 | 6.0 | -42.1 | -35.5 |
| EBITA margin | -183.3% | -310.2% | -475.3% | 12.6% | -453.0% | 13.6% | -535.0% | -252.6% |
| Amortization of intangibles | 1.1 | 0.5 | 0.2 | 0.2 | | | | |
| EBIT [+] | -65.2 | -49.0 | -55.8 | 8.5 | -39.3 | 6.0 | -42.1 | -35.5 |
| EBIT growth | 33.3% | -12.3% | -756.2% | -121.6% | -750.1% | -114.4% | 18.5% | -444.0% |
| EBIT margin | -186.5% | -313.4% | -477.0% | 12.2% | -453.0% | 13.6% | -535.0% | -252.6% |
| Non-recurring items [+] | 0.9 | 17.4 | 2.6 | -4.6 | | 2.7 | 0.9 | |
| Asset impairment | | 23.2 | | | | 2.7 | 0.9 | |
| Loss on contingent liability | 0.9 | -5.8 | 2.6 | -4.6 | | | | |
| Interest expense, net [+] | 2.4 | 2.9 | 4.3 | 0.5 | -0.1 | -0.1 | 0.0 | -0.1 |
| Interest expense | 2.4 | 2.9 | 4.3 | 0.5 | | | | |
| Interest income | | | | | 0.1 | 0.1 | 0.0 | 0.1 |
| Change in value of contingent liability | | | | | 1.6 | 1.5 | -0.2 | |
| Pre-tax income | -68.5 | -69.3 | -62.7 | 12.6 | -39.3 | 3.4 | -42.9 | -35.4 |
| Income taxes | 0.0 | -1.6 | -11.7 | 1.8 | -0.1 | -1.0 | -0.4 | 0.0 |
| Tax rate | | 2.4% | 18.6% | 14.7% | 0.3% | | 0.8% | 0.0% |
| Minority interest | | | | -0.1 | 0.0 | | | |
| Net income | -68.6 | -67.7 | -51.0 | 10.8 | -39.1 | 4.4 | -42.6 | -35.4 |
| Net margin | -195.9% | -433.1% | -436.1% | 15.6% | -450.8% | 9.9% | -541.5% | -252.2% |
| |
| Basic EPS [+] | ($0.80) | ($0.87) | ($0.73) | $0.15 | ($0.56) | $0.06 | ($0.76) | ($1.02) |
| Growth | -7.8% | 19.7% | -570.2% | -127.5% | -967.4% | -108.5% | -25.2% | -427.8% |
| Diluted EPS [+] | ($0.80) | ($0.87) | ($0.73) | $0.15 | ($0.56) | $0.06 | ($0.76) | ($1.02) |
| Growth | -7.8% | 19.7% | -571.2% | -127.5% | -968.2% | -108.5% | -25.2% | -428.9% |
| |
| Shares outstanding (basic) [+] | 85.6 | 77.9 | 70.3 | 70.0 | 69.7 | 68.2 | 55.8 | 34.8 |
| Growth | 9.9% | 10.8% | 0.4% | 0.4% | 2.2% | 22.2% | 60.6% | 4.1% |
| Shares outstanding (diluted) [+] | 85.6 | 77.9 | 70.3 | 70.2 | 69.7 | 68.2 | 55.8 | 34.8 |
| Growth | 9.9% | 10.8% | 0.2% | 0.6% | 2.2% | 22.3% | 60.6% | 3.8% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |