| In millions, except per share items | Dec-31-11 | Dec-31-10 | Dec-31-09 | Dec-31-08 | Dec-31-07 | Dec-31-06 | Dec-31-05 | Dec-31-04 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K/A | 10-K |
| Revenue: | | | | | | | | |
| Product sales | 104.9 | 47.2 | 154.1 | | | | | |
| Manufacturing and development services | 24.8 | 22.7 | 50.7 | | | | | |
| Research and development collaborative agreements | 1.3 | 87.5 | 71.0 | | | | | |
| Total revenue | 131.0 | 157.4 | 275.7 | 48.4 | 41.9 | 209.2 | 228.7 | 219.5 |
| Total revenue growth | -16.8% | -42.9% | 469.5% | 15.7% | -80.0% | -8.5% | 4.2% | 14.7% |
| Costs and expenses: | | | | | | | | |
| Cost of product sales | 47.1 | 29.9 | 15.8 | | -3.7 | 238.8 | 228.7 | 235.0 |
| Cost of manufacturing and development services | 29.0 | 15.0 | 18.2 | | | | | |
| Research and development expenses | 196.2 | 196.4 | 173.7 | | | | | |
| Selling, general and administrative expenses | 158.8 | 106.8 | 61.1 | | | | | |
| Commercial collaboration expenses | 31.2 | | | | | | | |
| Facility-related exit credits | -1.7 | | 0.8 | | | | | |
| Total costs and expenses | 460.5 | 348.1 | 269.6 | | | | | |
| Income (loss) from operations | -329.6 | -190.8 | 6.2 | | | | | |
| Operating margin | -251.6% | -121.2% | 2.2% | | | | | |
| Investment income | 12.2 | 17.0 | 12.7 | | | | | |
| Interest expense | -62.1 | -59.5 | -58.4 | | | | | |
| Other income (expense) | -1.7 | 0.1 | -0.2 | | | | | |
| Income (loss) before taxes | -381.1 | -233.2 | 4.4 | -268.9 | -284.4 | -251.2 | -239.4 | -242.9 |
| |
| Income tax expense | | | | | | | | |
| Net income (loss) | -381.1 | -233.2 | 5.7 | | | | | |
| |
| Basic and diluted net income (loss) per share | ($1.97) | ($1.24) | $0.04 | | | | | |
| |
| Weighted average shares outstanding, basic and diluted | 193.7 | 187.8 | 149.3 | | | | | |