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| In millions, except per share items | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 |
| | 10-K | 10-K | 10-K | 10-K | S-1/A |
| Revenues: |
| North America | | | | 1,413.1 | 1,323.0 |
| Europe, Middle East and Africa | | | | 979.9 | 849.3 |
| Asia-Pacific | | | | 256.8 | 203.8 |
| Latin America | | | | 117.7 | 91.9 |
| Other | | | | 233.6 | 211.6 |
| Total revenues | 4,681.5 | 4,031.0 | 3,749.0 | 3,001.1 | 2,679.6 |
| Revenue growth [+] | 16.1% | 7.5% | 24.9% | 12.0% | |
| North America | | | | 6.8% | |
| Europe, Middle East and Africa | | | | 15.4% | |
| Asia-Pacific | | | | 26.0% | |
| Latin America | | | | 28.1% | |
| Reimbursed revenue | | | | 10.4% | |
| Cost of goods sold | 279.1 | 264.8 | 259.0 | 1,815.6 | 1,386.7 |
| Gross profit | 4,402.4 | 3,766.2 | 3,490.0 | 1,185.4 | 1,292.9 |
| Gross margin | 94.0% | 93.4% | 93.1% | 39.5% | 48.2% |
| Selling, general and administrative | 1,010.1 | 938.8 | 813.0 | 809.3 | 718.1 |
| Equity in earnings | 8.2 | 3.6 | 0.2 | | |
| Other operating expenses | 2,882.8 | 2,408.9 | 2,274.7 | | |
| EBITDA [+] | 796.7 | 686.9 | 661.4 | 655.2 | 574.8 |
| EBITDA growth | 16.0% | 3.9% | 1.0% | 14.0% | |
| EBITDA margin | 17.0% | 17.0% | 17.6% | 21.8% | 21.4% |
| Depreciation | 121.5 | 102.9 | 90.4 | 279.1 | 260.5 |
| EBITA | 675.2 | 584.0 | 571.0 | 376.1 | 314.3 |
| EBITA margin | 14.4% | 14.5% | 15.2% | 12.5% | 11.7% |
| Amortization of intangibles | 157.6 | 161.9 | 168.6 | | |
| EBIT [+] | 517.6 | 422.1 | 402.4 | 376.1 | 314.3 |
| EBIT growth | 22.6% | 4.9% | 7.0% | 19.7% | |
| EBIT margin | 11.1% | 10.5% | 10.7% | 12.5% | 11.7% |
| Non-recurring items [+] | 1.4 | 1.3 | 29.6 | 158.2 | 28.1 |
| Asset impairment | 1.4 | 1.3 | 29.6 | 43.5 | 28.1 |
| Interest expense | 216.9 | 311.7 | 263.6 | 253.9 | 203.3 |
| Interest expense | 216.9 | 311.7 | 263.6 | 253.9 | 203.3 |
| Other income (expense), net [+] | -111.7 | -49.7 | 37.5 | 52.5 | 84.0 |
| Gain (loss) on investments | 52.7 | -19.0 | 15.9 | | 61.6 |
| Gain (loss) on debt retirement | -93.5 | | | | |
| Other | -62.7 | -27.1 | 21.7 | -40.3 | |
| Pre-tax income | 187.5 | 59.3 | 146.6 | 16.5 | 166.9 |
| Income taxes | 18.8 | 3.0 | 39.6 | -284.4 | -16.0 |
| Tax rate | 10.0% | 5.0% | 27.0% | | |
| Minority interest | 6.9 | 4.9 | 2.7 | -4.8 | 0.2 |
| Net income | 120.2 | 54.7 | 96.3 | 296.0 | 183.1 |
| Net margin | 2.6% | 1.4% | 2.6% | 9.9% | 6.8% |
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| Basic EPS [+] | $0.35 | $0.20 | $0.34 | $1.02 | $0.59 |
| Growth | 79.9% | -43.3% | -66.1% | 73.4% | |
| Diluted EPS [+] | $0.35 | $0.19 | $0.34 | $1.01 | $0.58 |
| Growth | 78.0% | -43.5% | -65.8% | 74.2% | |
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| Dividends per share [+] | | $4.46 | | | |
| Growth | -100.0% | | | | |
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| Shares outstanding (basic) [+] | 341.2 | 279.3 | 279.2 | 291.0 | 312.1 |
| Growth | 22.2% | 0.0% | -4.1% | -6.7% | |
| Shares outstanding (diluted) [+] | 346.7 | 280.7 | 279.3 | 293.8 | 316.6 |
| Growth | 23.5% | 0.5% | -4.9% | -7.2% | |
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| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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